Blue cone electroretinogram amplitudes are related to dopamine function in cocaine-dependent patients

TY - JOUR

T1 - Blue cone electroretinogram amplitudes are related to dopamine function in cocaine-dependent patients

AU - Roy, Alec

AU - Roy, Monique

AU - Berman, Jeffrey

AU - Gonzalez, Bienvenido

N1 - Funding Information: We thank Cynthia Kuhn, Ph.D., of the Department of Pharmacology and Cancer Biology at Duke University Medical School for the CSF HVA assay. This research was supported by grant R01 DA 10336-02 to AR from the National Institute on Drug Abuse.

PY - 2003/2/15

Y1 - 2003/2/15

N2 - The objective of the study was to examine the relationship between an index of central dopamine function and electroretinographic (ERG) blue cone amplitudes in cocaine-dependent patients. Thus, 17 recently abstinent cocaine-dependent patients had an ERG performed. They also had a lumbar puncture for determination of cerebrospinal (CSF) concentrations of the dopamine metabolite homovanillic acid (HVA). It was found that patients who had reduced ERG blue cone b-wave amplitudes (<0.5 μV) had significantly lower concentrations of CSF HVA than patients who had ERG blue cone b-wave amplitudes greater than 0.5 μV. There was also a significant positive correlation between ERG blue cone amplitudes and CSF HVA concentrations. These results suggest the possibility that ERG blue cone amplitudes may be a neurobiologic marker related to central dopamine function in cocaine-dependent patients.

AB - The objective of the study was to examine the relationship between an index of central dopamine function and electroretinographic (ERG) blue cone amplitudes in cocaine-dependent patients. Thus, 17 recently abstinent cocaine-dependent patients had an ERG performed. They also had a lumbar puncture for determination of cerebrospinal (CSF) concentrations of the dopamine metabolite homovanillic acid (HVA). It was found that patients who had reduced ERG blue cone b-wave amplitudes (<0.5 μV) had significantly lower concentrations of CSF HVA than patients who had ERG blue cone b-wave amplitudes greater than 0.5 μV. There was also a significant positive correlation between ERG blue cone amplitudes and CSF HVA concentrations. These results suggest the possibility that ERG blue cone amplitudes may be a neurobiologic marker related to central dopamine function in cocaine-dependent patients.

KW - Cocaine

KW - Dopamine

KW - Electroretinogram

UR - http://www.scopus.com/inward/record.url?scp=0037442783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037442783&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/S0165-1781(02)00323-2

DO - https://doi.org/10.1016/S0165-1781(02)00323-2

M3 - Article

C2 - 12606020

SN - 0165-1781

VL - 117

SP - 191

EP - 195

JO - Psychiatry Research

JF - Psychiatry Research

IS - 2

ER -