Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway

Liming Zhu, Xiaojiao Cheng, Yanfei Ding, Jindong Shi, Huanyu Jin, Hong Wang, Yunlin Wu, Jing Ye, Yiming Lu, Timothy C. Wang, Chung S. Yang, Shui Ping Tu

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Bone marrow-derived myofibroblasts (BMFs) have been shown to promote tumor growth. Here, we found that BMFs or BMF conditioned medium (BMF-CM) induced cancer stem cell-like sphere formation of colon cancer cells. The co-cultured BMFs, but not co-cultured cancer cells, expressed higher levels of IL-6 than BMFs or cancer cells cultured alone. Anti-mouse IL-6 neutralizing antibody, JAK2 inhibitors and STAT3 knockdown in mouse cancer cells reduced BMF- and BMF-CM-induced sphere formation of colon cancer cells. When co-injected, BMFs significantly enhanced tumorigenesis of colon cancer cells in mice. Our results demonstrate that BMFs promote tumorigenesis via the activation of the IL-6/JAK2/STAT3 pathway.

Original languageEnglish (US)
Pages (from-to)80-89
Number of pages10
JournalCancer Letters
Volume343
Issue number1
DOIs
StatePublished - Feb 1 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Bone marrow-derived myofibroblasts
  • Cancer stem cell
  • Colon cancer
  • IL-6
  • STAT3

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