Bone regeneration in a rabbit critical-sized calvarial model using tyrosine-derived polycarbonate scaffolds

Jinku Kim, Maria Hanshella R. Magno, Heather Waters, Bruce A. Doll, Sean McBride, Pedro Alvarez, Aniq Darr, Amit Vasanji, Joachim Kohn, Jeffrey O. Hollinger

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Porous three-dimensional tyrosine-derived polycarbonate (TyrPC) scaffolds with a bimodal pore distribution were fabricated to mimic bone architecture using a combination of salt-leaching and phase separation techniques. TyrPC scaffolds degraded in register with bone regeneration during the 6-week study period and compressive moduli of the scaffolds were maintained >0.5MPa at 6 weeks of incubation in PBS at 37°C. The TyrPC scaffolds either unsupplemented or supplemented with recombinant human bone morphogenetic protein-2 (rhBMP-2) were implanted in a rabbit calvarial critical-sized defect (CSD) model and the TyrPC scaffolds treated with rhBMP-2 or TyrPC coated with calcium phosphate scaffold alone promoted bone regeneration in a rabbit calvarial CSD at 6 weeks postimplantation. A synthetic TyrPC polymeric scaffold either without a biological supplement or with a minimal dose of rhBMP-2 induced bone regeneration comparable to a commercially available bone graft substitute in a nonrodent CSD animal model.

Original languageEnglish (US)
Pages (from-to)1132-1139
Number of pages8
JournalTissue Engineering - Part A
Volume18
Issue number11-12
DOIs
StatePublished - Jun 1 2012

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Biomaterials

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