Bone turnover and circulating insulin-like growth factor-I increase after improved glycemic control in diabetes

M. T. Rosato, S. H. Schneider, S. A. Shapses

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Abstract

Metabolic factors that contribute to an altered rate of bone turnover in diabetes are not clear. In this study, 17 patients with diabetes and 12 age and weight-matched healthy subjects were examined at baseline and 2 months later. Blood and urine were analyzed for markers of bone resorption (pyridinoline {PYD}. deoxypyridinoline {DPD}), and bone formation (osteocalcin {OC}), insulin-like growth factor-I (IGF-I), and parathyroid hormone (PTH). Baseline values of OC were significantly lower in patients with diabetes compared to healthy subjects (2.8±1.4 vs 3.9±0.9 ng/ml; P ≤ 0.05), but pyridinium crosslink excretion did not differ. In diabetic patients there was an inverse correlation between OC and HbAIC (R = - 0.60; P ≤ 0.01) and between pyridinium crosslinks and glucose {PYD (R = -0.58; P ≤ 0.02); DPD (R = -0.60; P ≤ 0.02)}. In addition, IGF-I tended to correlate with OC (R = 0.46; P ≤ 0.06) in the diabetic patients. Thirteen of the patients with diabetes showed an improvement of glycemic control (decreased HbAIC and fasting blood glucose) at the second measurement. These 13 patients showed a an increase (P ≤ 0.05) in OC (+ 25%). PYD (+ 30%), DPD (+ 26%), and IGF-I (+ 34%); but no change in PTH. These data suggest that improved glycemic control in patients with diabetes is accompanied by an increase in bone turnover that may be mediated by circulating IGF- I.

Original languageEnglish (US)
Pages (from-to)A389
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology
  • Biochemistry
  • Biotechnology

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