Brain insulin signalling in metabolic homeostasis and disease

Thomas Scherer, Kenichi Sakamoto, Christoph Buettner

Research output: Contribution to journalReview articlepeer-review


Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ crosstalk. Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic or intranasal application of insulin provide evidence that brain insulin action might reduce food intake and, more importantly, regulates energy homeostasis by orchestrating nutrient partitioning. This Review discusses the metabolic pathways that are under the control of brain insulin action and explains how brain insulin resistance contributes to metabolic disease in obesity, the metabolic syndrome and type 2 diabetes mellitus.

Original languageAmerican English
Pages (from-to)468-483
Number of pages16
JournalNature Reviews Endocrinology
Issue number8
StatePublished - Aug 2021

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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