Brown and beige fat: From molecules to physiology

Maria Chondronikola, Labros Sidossis

Research output: Contribution to journalReview article

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Abstract

The recent re-discovery of brown adipose tissue (BAT) and even more recent discovery of the browning of white adipose tissue (WAT) in humans have generated intense scientific interest in the role of adipose tissue as potential target against obesity and its metabolic complications. The purpose of this review is to: i) critically evaluate the current evidence on the physiological significance of BAT and the browning of WAT in metabolic function in humans and ii) discuss factors that have been reported to regulate BAT and/or the browning of WAT in humans. The current literature supports that BAT and the browning of WAT constitute promising emerging targets for interventions aiming to prevent and/or treat of obesity and its metabolic complications. Further research is needed to better understand the physiological significance of BAT and browning of WAT in health and disease along with the factors modulating their metabolic function in humans.

LanguageEnglish (US)
Pages91-103
Number of pages13
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1864
Issue number1
DOIs
StatePublished - Jan 1 2019

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White Adipose Tissue
Brown Adipose Tissue
Obesity
Adipose Tissue
Beige Adipose Tissue
Health
Research

Cite this

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Brown and beige fat : From molecules to physiology. / Chondronikola, Maria; Sidossis, Labros.

In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1864, No. 1, 01.01.2019, p. 91-103.

Research output: Contribution to journalReview article

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