Building a model of the brain: from detailed connectivity maps to network organization

Renan Oliveira Shimoura, Vinicius Lima, Nilton L. Kamiji, Mauricio Girardi-Schappo, Antonio C. Roque

Research output: Contribution to journalReview articlepeer-review


The field of computational modeling of the brain is advancing so rapidly that now it is possible to model large scale networks representing different brain regions with a high level of biological detail in terms of numbers of neurons and synapses. For a theoretician approaching a neurobiological question, it is important to analyze the pros and cons of each of the models available. Here, we provide a tutorial review on recent models for different brain circuits, which are based on experimentally obtained connectivity maps. We discuss particularities that may be relevant to the modeler when choosing one of the reviewed models. The objective of this review is to give the reader a fair notion of the computational models covered, with emphasis on the corresponding connectivity maps, and how to use them.

Original languageAmerican English
Pages (from-to)2887-2909
Number of pages23
JournalEuropean Physical Journal: Special Topics
Issue number14-15
StatePublished - Oct 2021

ASJC Scopus subject areas

  • General Materials Science
  • General Physics and Astronomy
  • Physical and Theoretical Chemistry

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