Burning cold: Involvement of TRPA1 in noxious cold sensation

Kelvin Y. Kwan; David P. Corey

doi:10.1085/jgp.200810146

Burning cold: Involvement of TRPA1 in noxious cold sensation

Kelvin Y. Kwan, David P. Corey

School of Arts and Sciences, Center for Collaborative Neuroscience

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below ̃15 ° C) has been mixed, however. Some groups found that cold elicits a nonselective conductance in cells expressing TRPA1; others found no activation, or argued that activation is an indirect effect of elevated Ca ²⁺ . Sensory cells from the trigeminal and dorsal root ganglia that are activated by cold were sometimes correlated with those cells expressing TRPA1; other times not. Mice lacking TRPA1 showed behavioral defi cits for some assays of painful cold sensation, but not others. New evidence tends to support direct activation of TRPA1 by cold, and the slow and relatively weak activation of TRPA1 by cold helps reconcile some confl icting studies.

Original language	American English
Pages (from-to)	251-256
Number of pages	6
Journal	Journal of General Physiology
Volume	133
Issue number	3
DOIs	https://doi.org/10.1085/jgp.200810146
State	Published - Mar 2009

ASJC Scopus subject areas

Physiology

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title = "Burning cold: Involvement of TRPA1 in noxious cold sensation",

abstract = "Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below{\~ }15 ° C) has been mixed, however. Some groups found that cold elicits a nonselective conductance in cells expressing TRPA1; others found no activation, or argued that activation is an indirect effect of elevated Ca 2+ . Sensory cells from the trigeminal and dorsal root ganglia that are activated by cold were sometimes correlated with those cells expressing TRPA1; other times not. Mice lacking TRPA1 showed behavioral defi cits for some assays of painful cold sensation, but not others. New evidence tends to support direct activation of TRPA1 by cold, and the slow and relatively weak activation of TRPA1 by cold helps reconcile some confl icting studies.",

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N2 - Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below ̃15 ° C) has been mixed, however. Some groups found that cold elicits a nonselective conductance in cells expressing TRPA1; others found no activation, or argued that activation is an indirect effect of elevated Ca 2+ . Sensory cells from the trigeminal and dorsal root ganglia that are activated by cold were sometimes correlated with those cells expressing TRPA1; other times not. Mice lacking TRPA1 showed behavioral defi cits for some assays of painful cold sensation, but not others. New evidence tends to support direct activation of TRPA1 by cold, and the slow and relatively weak activation of TRPA1 by cold helps reconcile some confl icting studies.

AB - Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below ̃15 ° C) has been mixed, however. Some groups found that cold elicits a nonselective conductance in cells expressing TRPA1; others found no activation, or argued that activation is an indirect effect of elevated Ca 2+ . Sensory cells from the trigeminal and dorsal root ganglia that are activated by cold were sometimes correlated with those cells expressing TRPA1; other times not. Mice lacking TRPA1 showed behavioral defi cits for some assays of painful cold sensation, but not others. New evidence tends to support direct activation of TRPA1 by cold, and the slow and relatively weak activation of TRPA1 by cold helps reconcile some confl icting studies.

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Burning cold: Involvement of TRPA1 in noxious cold sensation

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