Cachexia: A systemic consequence of progressive, unresolved disease

Miriam Ferrer, Tracy G. Anthony, Janelle S. Ayres, Giulia Biffi, Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Anthony P. Coll, Richard F. Dunne, Marcus D. Goncalves, Jonas Grethlein, Steven B. Heymsfield, Sheng Hui, Mariam Jamal-Hanjani, Jie Min Lam, David Y. Lewis, David McCandlish, Karen M. Mustian, Stephen O'Rahilly, Norbert PerrimonEileen P. White, Tobias Janowitz

Research output: Contribution to journalReview articlepeer-review

Abstract

Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.

Original languageEnglish (US)
Pages (from-to)1824-1845
Number of pages22
JournalCell
Volume186
Issue number9
DOIs
StatePublished - Apr 27 2023

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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