Abstract
The exact mechanisms that cause myocardial stunning are still unclear. We previously utilized a computer model of the ventricle that was effective in modeling the dominant observable features of stunning, but it was not simple to implement. This led to the design of a single muscle fiber model. The mathematical model of a muscle fiber consisted of three elements: a contractile element, a series elastic element, and a parallel elastic element. The model created length waveforms based on time-dependent force and contractile stiffness functions. This model was initially evaluated by entering the same regional parameter values used in the global dual region ventricular model. First a reduction of the contractile stiffness function was applied by reducing the peak stiffness by 30%, and then the rates of activation and deactivation were reduced by 20% while maintaining the peak values constant. The three-element model produced results very similar to the canine and ventricular model. Thus, it is concluded that the simpler three-element model provides an accurate model of the myocardial tissue and its deficiencies during stunning.
| Original language | American English |
|---|---|
| Pages (from-to) | 31-38 |
| Number of pages | 8 |
| Journal | Cardiovascular Engineering |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2003 |
ASJC Scopus subject areas
- Surgery
- Cardiology and Cardiovascular Medicine
- Transplantation
Keywords
- Muscle modeling
- Myocardial stunning
- Stunning mechanisms