Abstract
Intestinal fructose transport is enhanced only after completion of weaning by rats allowed to develop normally. Fructose absorption however, can be precociously enhanced in 15 or 22 d-old weaning rats given a high (65%) fructose diet and is an excellent model for studying precocious enhancement of transport systems during development. In this study, we determined whether dietary fructose enhances fructose transport in the suckling rat small intestine. We fed by gavage 10 and 14 d-old suckling rats sugar solutions containing high fructose (HF), high glucose (HG) or high mannitol (HM) at a volume of 2% body weight 2X per d for 2 d. Pups stayed with dams at all other times. Intestinal fructose uptake was independent of diet (control=dam's milk-fed) in 10 d-old rats sacrificed at 12 d of age, and increased 2X in HF-fed 14 d-old rats sacrificed at 16 d. To validate the effectiveness of gavage feeding, we fed for 2 d 20 d-old pups HF or HG pellets, or HF, HG or HM solutions by gavage. Intestinal fructose uptake was enhanced 2-3X by HF solutions or pellets. In contrast, intestinal glucose transport was independent of diet in all experiments. Hence, induction of intestinal fructose transport is possible only during periweaning and weaning, but not during suckling stage. These findings provide a basis for studying control of transporter gene expression during development.
| Original language | American English |
|---|---|
| Pages (from-to) | A122 |
| Journal | FASEB Journal |
| Volume | 10 |
| Issue number | 3 |
| State | Published - 1996 |
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Genetics
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