TY - JOUR
T1 - Can motor function uncertainty and local instability within upper-extremity dual-tasking predict amnestic mild cognitive impairment and early-stage Alzheimer's disease?
AU - Ehsani, Hossein
AU - Parvaneh, Saman
AU - Mohler, Jane
AU - Wendel, Christopher
AU - Zamrini, Edward
AU - O'Connor, Kathy
AU - Toosizadeh, Nima
N1 - Publisher Copyright: © 2020 Elsevier Ltd
PY - 2020/5
Y1 - 2020/5
N2 - In this study, we examined the uncertainty and local instability of motor function for cognitive impairment screening using a previously validated upper-extremity function (UEF). This approach was established based upon the fact that elders with an impaired executive function have trouble in the simultaneous execution of a motor and a cognitive task (dual-tasking). Older adults aged 65 years and older were recruited and stratified into 1) cognitive normal (CN), 2) amnestic MCI of the Alzheimer's type (aMCI), and 3) early-stage Alzheimer's Disease (AD). Participants performed normal-paced repetitive elbow flexion without counting and while counting backward by ones and threes. The influence of cognitive task on motor function was measured using uncertainty (measured by Shannon entropy), and local instability (measured by the largest Lyapunov exponent) of elbow flexion and compared between cognitive groups using ANOVAs, while adjusting for age, sex, and BMI. We developed logistic ordinal regression models for predicting cognitive groups based on these nonlinear measures. A total of 81 participants were recruited, including 35 CN (age = 83.8 ± 6.9), 30 aMCI (age = 83.9 ± 6.9), and 16 early AD (age = 83.2 ± 6.6). Uncertainty of motor function demonstrated the strongest associations with cognitive impairment, with an effect size of 0.52, 0.88, and 0.51 for CN vs. aMCI, CN vs. AD, and aMCI vs. AD comparisons, respectively. Ordinal logistic models predicted cognitive impairment (aMCI and AD combined) with a sensitivity and specificity of 0.82. The findings accentuate the potential of employing nonlinear dynamical features of motor functions during dual-tasking, especially uncertainty, in detecting cognitive impairment.
AB - In this study, we examined the uncertainty and local instability of motor function for cognitive impairment screening using a previously validated upper-extremity function (UEF). This approach was established based upon the fact that elders with an impaired executive function have trouble in the simultaneous execution of a motor and a cognitive task (dual-tasking). Older adults aged 65 years and older were recruited and stratified into 1) cognitive normal (CN), 2) amnestic MCI of the Alzheimer's type (aMCI), and 3) early-stage Alzheimer's Disease (AD). Participants performed normal-paced repetitive elbow flexion without counting and while counting backward by ones and threes. The influence of cognitive task on motor function was measured using uncertainty (measured by Shannon entropy), and local instability (measured by the largest Lyapunov exponent) of elbow flexion and compared between cognitive groups using ANOVAs, while adjusting for age, sex, and BMI. We developed logistic ordinal regression models for predicting cognitive groups based on these nonlinear measures. A total of 81 participants were recruited, including 35 CN (age = 83.8 ± 6.9), 30 aMCI (age = 83.9 ± 6.9), and 16 early AD (age = 83.2 ± 6.6). Uncertainty of motor function demonstrated the strongest associations with cognitive impairment, with an effect size of 0.52, 0.88, and 0.51 for CN vs. aMCI, CN vs. AD, and aMCI vs. AD comparisons, respectively. Ordinal logistic models predicted cognitive impairment (aMCI and AD combined) with a sensitivity and specificity of 0.82. The findings accentuate the potential of employing nonlinear dynamical features of motor functions during dual-tasking, especially uncertainty, in detecting cognitive impairment.
KW - Biomechanics
KW - Computer modeling
KW - Early detection
KW - Executive function
KW - Largest Lyapunov exponent
KW - MCI
KW - Motor control
KW - Nonlinear dynamical systems
KW - Shannon entropy
KW - Wearable motion sensors
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U2 - 10.1016/j.compbiomed.2020.103705
DO - 10.1016/j.compbiomed.2020.103705
M3 - Article
C2 - 32217286
SN - 0010-4825
VL - 120
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
M1 - 103705
ER -