Cardiorespiratory Fitness, Adiposity, and Cancer Mortality in Men

Baruch Vainshelboim, Zhongming Chen, Yvonne Nicole Lee, Aryo Sorayya, Peter Kokkinos, Kevin T. Nead, Cariad Chester, Jonathan Myers

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: This study sought to evaluate the association between cardiorespiratory fitness (CRF) and cancer mortality in men with overweight and obesity. Methods: Maximal exercise testing was performed in 3,610 men (58.8 ± 17.5 years) (n = 2,100 with overweight and n = 1,510 with obesity) free from malignancy at baseline who were followed for 12.3 ± 7.4 years. Body mass index of 25.0 to 29.9 kg/m2 for overweight and ≥ 30.0 for obesity categories was used. Hazard ratios and population-attributable risks (PAR) were determined. Results: During the follow-up period, 11.1% and 9.1% died from cancer among those who had overweight and obesity, respectively. CRF had an inverse and graded association with cancer mortality. Compared with low CRF (< 5 metabolic equivalents), moderate and high CRF levels were associated with 48% and 79% reduced risks for cancer mortality in men who had overweight (P < 0.001) and 55% and 83% lower risks in those who had obesity (P < 0.001), respectively. Low CRF had PARs of 9.3% and 10.5% for cancer mortality in subjects who had overweight and obesity, respectively. Conclusions: Among men with overweight and obesity, higher CRF is associated with lower cancer mortality. Eliminating low CRF as a risk factor would potentially prevent a considerable number of cancer deaths and reduce the associated societal and economic burden in these high-risk populations.

Original languageEnglish (US)
Pages (from-to)S66-S71
StatePublished - Nov 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Nutrition and Dietetics
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism


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