CD8+ Tissue-Resident Memory T Cells: Versatile Guardians of the Tissue

Corey Gallen, Tessa Bergsbaken

Research output: Contribution to journalArticlepeer-review

Abstract

Tissue-resident memory T (Trm) cells are a subset of T cells maintained throughout life within nonlymphoid tissues without significant contribution from circulating memory T cells. CD8+ Trm cells contribute to both tissue surveillance and direct elimination of pathogens through a variety of mechanisms. Reactivation of these Trm cells during infection drives systematic changes within the tissue, including altering the state of the epithelium, activating local immune cells, and contributing to the permissiveness of the tissue for circulating immune cell entry. Trm cells can be further classified by their functional outputs, which can be either subset- or tissue-specific, and include proliferation, tissue egress, and modulation of tissue physiology. These functional outputs of Trm cells are linked to the heterogeneity and plasticity of this population, and uncovering the unique responses of different Trm cell subsets and their role in immunity will allow us to modulate Trm cell responses for optimal control of disease.

Original languageAmerican English
Pages (from-to)361-368
Number of pages8
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume212
Issue number3
DOIs
StatePublished - Feb 1 2024

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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