Cell depletion in synthetic micro-thrombosis

On the enhanced FåHraeus effect

Magalie Faivre, Manouk Abkarian, Kimberly Bikraj, Howard A. Stone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is well known that when a suspension of cells flows in a small capillary there exists a cell-free layer adjacent to the walls. We show experimentally that a constriction in the flow can dramatically enhance the cell-free layer downstream. The effects of the constriction geometry, flow rate, suspending fluid viscosity, cell concentration, and cell deformability are studied and the results are interpreted in terms of a model of the hydrodynamic drift of a cell in a quadratic flow. As our observations indicate that the constriction causes dramatic modifications of the cell distribution, the results may have major implications for shear stress-triggered mechanotransduction, oxygen transport, and wound healing downstream of remodeled arteries.

Original languageEnglish (US)
Title of host publication05AIChE
Subtitle of host publication2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings
Number of pages1
StatePublished - Dec 1 2005
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: Oct 30 2005Nov 4 2005

Other

Other05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
CountryUnited States
CityCincinnati, OH
Period10/30/0511/4/05

Fingerprint

thrombosis
depletion
cells
constrictions
wound healing
arteries
shear stress
flow velocity
hydrodynamics
viscosity
causes
fluids
oxygen
geometry

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Faivre, M., Abkarian, M., Bikraj, K., & Stone, H. A. (2005). Cell depletion in synthetic micro-thrombosis: On the enhanced FåHraeus effect. In 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings
Faivre, Magalie ; Abkarian, Manouk ; Bikraj, Kimberly ; Stone, Howard A. / Cell depletion in synthetic micro-thrombosis : On the enhanced FåHraeus effect. 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings. 2005.
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Faivre, M, Abkarian, M, Bikraj, K & Stone, HA 2005, Cell depletion in synthetic micro-thrombosis: On the enhanced FåHraeus effect. in 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings. 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States, 10/30/05.

Cell depletion in synthetic micro-thrombosis : On the enhanced FåHraeus effect. / Faivre, Magalie; Abkarian, Manouk; Bikraj, Kimberly; Stone, Howard A.

05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings. 2005.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - It is well known that when a suspension of cells flows in a small capillary there exists a cell-free layer adjacent to the walls. We show experimentally that a constriction in the flow can dramatically enhance the cell-free layer downstream. The effects of the constriction geometry, flow rate, suspending fluid viscosity, cell concentration, and cell deformability are studied and the results are interpreted in terms of a model of the hydrodynamic drift of a cell in a quadratic flow. As our observations indicate that the constriction causes dramatic modifications of the cell distribution, the results may have major implications for shear stress-triggered mechanotransduction, oxygen transport, and wound healing downstream of remodeled arteries.

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Faivre M, Abkarian M, Bikraj K, Stone HA. Cell depletion in synthetic micro-thrombosis: On the enhanced FåHraeus effect. In 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings. 2005