Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes

Md Zulfikar Ali; Kerwyn Casey Huang; Ned S. Wingreen; Ranjan Mukhopadhyay

doi:10.1103/PhysRevE.99.012401

Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes

Md Zulfikar Ali, Kerwyn Casey Huang, Ned S. Wingreen, Ranjan Mukhopadhyay

Princeton University

Research output: Contribution to journal › Article › peer-review

Abstract

We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization.

Original language	American English
Article number	012401
Journal	Physical Review E
Volume	99
Issue number	1
DOIs	https://doi.org/10.1103/PhysRevE.99.012401
State	Published - Jan 2 2019

ASJC Scopus subject areas

Condensed Matter Physics
Statistical and Nonlinear Physics
Statistics and Probability

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10.1103/PhysRevE.99.012401

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abstract = "We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization.",

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AB - We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization.

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Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes

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