Abstract

Identifying cell trajectories is an important step in analyzing physiological events in computerized Video Time-lapse Microcopy. The large variety and transformation of cell shapes and cells' Brownian motion make cell tracking a challenge problem. In this paper we present a cell tracking system, implemented as a particle filter within texture-adaptive active contour formulations. The texture-adaptive weights on the external energy of the active contour model enables snakes to bypass internal psuedo-edges and stop on low-contrast cell boundaries. Using the texture of cells as observation model, we can track cells whose locations follow a multimodal distribution with a particle filter. This system is a novel combination of tracking algorithms and deformable models, and allows for the first time to automatically track non-fluorescence cellular microscopy images. The implemented tracker is tested on both normal and autophagy cell image sequences, to demonstrate the properties of cells in autophagy.

Original languageEnglish (US)
Title of host publication2007 4th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages101-104
Number of pages4
DOIs
StatePublished - Nov 27 2007
Event2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States
Duration: Apr 12 2007Apr 15 2007

Publication series

Name2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings

Other

Other2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
CountryUnited States
CityArlington, VA
Period4/12/074/15/07

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Electrical and Electronic Engineering

Keywords

  • Biomedical microscopy
  • Image segmentation
  • Image texture analysis
  • Tracking

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  • Cite this

    Wang, X., He, W., Metaxas, D., Mathew, R., & White, E. (2007). Cell segmentation and tracking using texture-adaptive snakes. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 101-104). [4193232] (2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings). https://doi.org/10.1109/ISBI.2007.356798