Cellular and molecular mechanisms regulating airway smooth muscle physiology and pharmacology

Research output: Contribution to journalReview article

Abstract

Airway smooth muscle (ASM) in asthma is the pivotal cell regulating bronchomotor tone. Recent evidence suggests that ASM may also modulate airway inflammation and perpetuate airway remodeling. A variety of signaling pathways regulate ASM cytokine-chemokine secretion as well as cell adhesion molecule expression. Interestingly, these signaling pathways appear to be disparate from those of trafficking leukocytes. In this review, excitation-contraction coupling as well as synthetic function of ASM, defined as the ability to secrete immunomodulatory cytokines and chemokines and to express cell surface receptors that are important in cell adhesion and leukocyte activation, will be reviewed. Pharmacologic approaches to modify the synthetic function of ASM and how altered synthetic function may contribute to airway remodeling will also be defined.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalJournal of Organ Dysfunction
Volume2
Issue number1
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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Smooth Muscle
Pharmacology
Airway Remodeling
Chemokines
Leukocytes
Cytokines
Excitation Contraction Coupling
Cell Adhesion Molecules
Cell Surface Receptors
Cell Adhesion
Asthma
Inflammation

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine
  • Critical Care
  • Molecular Biology
  • Physiology

Cite this

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abstract = "Airway smooth muscle (ASM) in asthma is the pivotal cell regulating bronchomotor tone. Recent evidence suggests that ASM may also modulate airway inflammation and perpetuate airway remodeling. A variety of signaling pathways regulate ASM cytokine-chemokine secretion as well as cell adhesion molecule expression. Interestingly, these signaling pathways appear to be disparate from those of trafficking leukocytes. In this review, excitation-contraction coupling as well as synthetic function of ASM, defined as the ability to secrete immunomodulatory cytokines and chemokines and to express cell surface receptors that are important in cell adhesion and leukocyte activation, will be reviewed. Pharmacologic approaches to modify the synthetic function of ASM and how altered synthetic function may contribute to airway remodeling will also be defined.",
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Cellular and molecular mechanisms regulating airway smooth muscle physiology and pharmacology. / Panettieri, Reynold.

In: Journal of Organ Dysfunction, Vol. 2, No. 1, 01.03.2006, p. 37-47.

Research output: Contribution to journalReview article

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