Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades

Michael L. Gatza; Julie C. Watt; Susan J. Marriott

doi:10.1038/sj.onc.1206549

Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades

Michael L. Gatza
, Julie C. Watt
, Susan J. Marriott

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated myelopathy/tropical spastic paraparesis. HTLV-I encodes an oncogenic protein, Tax, which affects a variety of cellular functions prompting it to be referred to as a jack-of-all trades. The ability of Tax to both transcriptionally regulate cellular gene expression and to functionally inactivate proteins involved in cell-cycle progression and DNA repair provide the basis for Tax-mediated transformation and leukemogenesis. This review will concentrate on the effects of Tax on the dysregulation of the G₁/S and Gz/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation.

Original language	American English
Pages (from-to)	5141-5149
Number of pages	9
Journal	Oncogene
Volume	22
Issue number	33 REV. ISS. 2
DOIs	https://doi.org/10.1038/sj.onc.1206549
State	Published - Aug 11 2003
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Keywords

Cell cycle
Cellular transformation
DNA repair
HTLV-I
Tax

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10.1038/sj.onc.1206549

Cite this

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title = "Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades",

abstract = "The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated myelopathy/tropical spastic paraparesis. HTLV-I encodes an oncogenic protein, Tax, which affects a variety of cellular functions prompting it to be referred to as a jack-of-all trades. The ability of Tax to both transcriptionally regulate cellular gene expression and to functionally inactivate proteins involved in cell-cycle progression and DNA repair provide the basis for Tax-mediated transformation and leukemogenesis. This review will concentrate on the effects of Tax on the dysregulation of the G1/S and Gz/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation.",

keywords = "Cell cycle, Cellular transformation, DNA repair, HTLV-I, Tax",

author = "Gatza, \{Michael L.\} and Watt, \{Julie C.\} and Marriott, \{Susan J.\}",

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T1 - Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades

AU - Gatza, Michael L.

AU - Watt, Julie C.

AU - Marriott, Susan J.

PY - 2003/8/11

Y1 - 2003/8/11

N2 - The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated myelopathy/tropical spastic paraparesis. HTLV-I encodes an oncogenic protein, Tax, which affects a variety of cellular functions prompting it to be referred to as a jack-of-all trades. The ability of Tax to both transcriptionally regulate cellular gene expression and to functionally inactivate proteins involved in cell-cycle progression and DNA repair provide the basis for Tax-mediated transformation and leukemogenesis. This review will concentrate on the effects of Tax on the dysregulation of the G1/S and Gz/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation.

AB - The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated myelopathy/tropical spastic paraparesis. HTLV-I encodes an oncogenic protein, Tax, which affects a variety of cellular functions prompting it to be referred to as a jack-of-all trades. The ability of Tax to both transcriptionally regulate cellular gene expression and to functionally inactivate proteins involved in cell-cycle progression and DNA repair provide the basis for Tax-mediated transformation and leukemogenesis. This review will concentrate on the effects of Tax on the dysregulation of the G1/S and Gz/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation.

KW - Cell cycle

KW - Cellular transformation

KW - DNA repair

KW - HTLV-I

KW - Tax

UR - https://www.scopus.com/pages/publications/0042467680

UR - https://www.scopus.com/pages/publications/0042467680#tab=citedBy

U2 - 10.1038/sj.onc.1206549

DO - 10.1038/sj.onc.1206549

M3 - Review article

C2 - 12910251

SN - 0950-9232

VL - 22

SP - 5141

EP - 5149

JO - Oncogene

JF - Oncogene

IS - 33 REV. ISS. 2

ER -

Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades

Abstract

ASJC Scopus subject areas

Keywords

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