Central administration of neuropeptide Y induces precocious puberty in female rats

S. Minami, D. K. Sarkar

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


To examine the role of neuropeptide Y (NPY) in the regulation of puberty, the effects of various doses of NPY or saline injected into the 3rd ventricle of peripubertal female rats were determined. A single injection of NPY at a dose range of 10-20 μg into the 3rd ventricle of 30-day-old female rats advanced the time of vaginal opening (VO) and first ovulation by 4 days, as compared to saline-treated controls. Ova number and ovarian, adrenal and uterine weights at first estrous were similar in all animals regardless of treatment. The NPY-treated precocious animals showed lower body weight than did the VO-matched controls, but showed similar body weight as that of age-matched controls. Determination of plasma luteinizing hormone (LH) levels in the peripubertal female rats revealed that plasma LH was increased transiently immediately after NPY administration. Also, NPY-treated rats which had precocious puberty showed elevated pituitary and plasma LH levels on the day of VO. These results suggest that NPY can activate the hypothalamic-pituitary-gonadal axis to precociously initiate puberty.

Original languageEnglish (US)
Pages (from-to)930-934
Number of pages5
Issue number6
StatePublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Cellular and Molecular Neuroscience
  • Endocrinology, Diabetes and Metabolism


  • Body weight
  • Female rat
  • Gonadal weight
  • Luteinizing hormone
  • Neuropeptide Y
  • Ovulation
  • Pituitary and plasma luteinizing hormone
  • Puberty


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