Centrifuge-based deterministic lateral displacement separation

Mingliang Jiang, Aaron D. Mazzeo, German Drazer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


This work investigates the migration of spherical particles of different sizes in a centrifuge-driven deterministic lateral displacement device. Specifically, we use a scaled-up model to study the motion of suspended particles through a square array of cylindrical posts under the action of centrifugation. Experiments show that separation of particles by size is possible depending on the orientation of the driving acceleration with respect to the array of posts (forcing angle). We focus on the fractionation of binary suspensions and measure the separation resolution at the outlet of the device for different forcing angles. We found excellent resolution at intermediate forcing angles, when large particles are locked to move at small migration angles, but smaller particles follow the forcing angle more closely. Finally, we show that reducing the initial concentration (number) of particles, approaching the dilute limit of single particles, leads to increased resolution in the separation.

Original languageEnglish (US)
Article number17
Pages (from-to)1-10
Number of pages10
JournalMicrofluidics and Nanofluidics
Issue number1
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry


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