Cerebral regional capillary perfusion and blood flow after carbon monoxide exposure

A. K. Sinha, J. Klein, P. Schultze, J. Weiss, H. R. Weiss

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Alterations in regional cerebral blood flow (rCBF) and percent perfused capillaries (indicative of functional intercapillary distance) were determined in conscious male Long-Evans rats after reducing their blood O2-carrying capacity by exposing them to 1% CO for 12 min. rCBF was determined by the iodoantipyrine method. rCBF increased from a mean of 106 ± 8 (SE) ml · min-1 · 100 g-1 before CO exposure to 173 ± 14 ml · min-1 · 100 g-1 after CO exposure. There was a greater flow increase (126%) in the cerebral cortex than in the lower brain stem [pons (45%), medulla (39%)]. Presence of fluorescein isothiocyanate-labeled dextran identified the perfused capillaries before and after CO exposure. The volume fraction (Vv) and number/mm2 (N(a)) of all capillaries (perfused and nonperfused) in a given area of brain were determined after staining for alkaline phosphatase. The percent Vv and percent N(a) of perfused capillaries increased uniformly (from ~50% to ~80%) in all parts of the brain after CO exposure. In the presence of tissue hypoxia with undiminished plasma PO2, the brain vasculature allowed greater flow of blood while the microvasculature adjusted to reduce the diffusion distance for O2.

Original languageEnglish (US)
Pages (from-to)1196-1200
Number of pages5
JournalJournal of applied physiology
Issue number4
StatePublished - 1991

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


  • brain
  • cerebral blood flow
  • rat


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