Cerebral vascular responses to changes in carbon dioxide tension in term and preterm infants with apnea

Anne Koons; Thomas Hegyi; Rajeev Mehta; Mark Hiatt; Barry Weinberger

doi:https://doi.org/10.1159/000071945

Cerebral vascular responses to changes in carbon dioxide tension in term and preterm infants with apnea

Anne Koons, Thomas Hegyi, Rajeev Mehta, Mark Hiatt, Barry Weinberger

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Carbon dioxide (CO₂) plays important roles in regulating both respiratory drive and cerebral blood flow. These effects are mediated, in part, by activity of the sympathetic nervous system. We hypothesized that the presence of acute life-threatening events or apnea in term or preterm infants, respectively, would serve as a marker for immaturity of cerebral autonomic innervation and that such infants would display a reduced cerebral vascular response to elevated pCO₂. Therefore, we evaluated the cerebral vascular response during CO₂ challenge tests in groups of term and preterm infants with primary apnea. In term infants (39 ± 2 weeks gestation) with acute life-threatening events, elevated pCO₂ was accompanied by decreasing pulsatility index and increasing mean anterior cerebral blood flow velocity. However, in preterm infants (29 ± 2 weeks' gestation) with apnea, pulsatility index and anterior cerebral artery flow velocity did not significantly change in response to CO₂ supplementation. We conclude that preterm, but not term, infants with apnea exhibit impaired vascular responses to hypercarbia.

Original language	English (US)
Pages (from-to)	115-118
Number of pages	4
Journal	Biology of the Neonate
Volume	84
Issue number	2
DOIs	https://doi.org/10.1159/000071945
State	Published - 2003

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Biology

Keywords

Apnea
Carbon dioxide
Cerebral blood flow

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https://doi.org/10.1159/000071945

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title = "Cerebral vascular responses to changes in carbon dioxide tension in term and preterm infants with apnea",

abstract = "Carbon dioxide (CO2) plays important roles in regulating both respiratory drive and cerebral blood flow. These effects are mediated, in part, by activity of the sympathetic nervous system. We hypothesized that the presence of acute life-threatening events or apnea in term or preterm infants, respectively, would serve as a marker for immaturity of cerebral autonomic innervation and that such infants would display a reduced cerebral vascular response to elevated pCO2. Therefore, we evaluated the cerebral vascular response during CO2 challenge tests in groups of term and preterm infants with primary apnea. In term infants (39 ± 2 weeks gestation) with acute life-threatening events, elevated pCO2 was accompanied by decreasing pulsatility index and increasing mean anterior cerebral blood flow velocity. However, in preterm infants (29 ± 2 weeks' gestation) with apnea, pulsatility index and anterior cerebral artery flow velocity did not significantly change in response to CO2 supplementation. We conclude that preterm, but not term, infants with apnea exhibit impaired vascular responses to hypercarbia.",

keywords = "Apnea, Carbon dioxide, Cerebral blood flow",

author = "Anne Koons and Thomas Hegyi and Rajeev Mehta and Mark Hiatt and Barry Weinberger",

year = "2003",

doi = "https://doi.org/10.1159/000071945",

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TY - JOUR

T1 - Cerebral vascular responses to changes in carbon dioxide tension in term and preterm infants with apnea

AU - Koons, Anne

AU - Hegyi, Thomas

AU - Mehta, Rajeev

AU - Hiatt, Mark

AU - Weinberger, Barry

PY - 2003

Y1 - 2003

N2 - Carbon dioxide (CO2) plays important roles in regulating both respiratory drive and cerebral blood flow. These effects are mediated, in part, by activity of the sympathetic nervous system. We hypothesized that the presence of acute life-threatening events or apnea in term or preterm infants, respectively, would serve as a marker for immaturity of cerebral autonomic innervation and that such infants would display a reduced cerebral vascular response to elevated pCO2. Therefore, we evaluated the cerebral vascular response during CO2 challenge tests in groups of term and preterm infants with primary apnea. In term infants (39 ± 2 weeks gestation) with acute life-threatening events, elevated pCO2 was accompanied by decreasing pulsatility index and increasing mean anterior cerebral blood flow velocity. However, in preterm infants (29 ± 2 weeks' gestation) with apnea, pulsatility index and anterior cerebral artery flow velocity did not significantly change in response to CO2 supplementation. We conclude that preterm, but not term, infants with apnea exhibit impaired vascular responses to hypercarbia.

AB - Carbon dioxide (CO2) plays important roles in regulating both respiratory drive and cerebral blood flow. These effects are mediated, in part, by activity of the sympathetic nervous system. We hypothesized that the presence of acute life-threatening events or apnea in term or preterm infants, respectively, would serve as a marker for immaturity of cerebral autonomic innervation and that such infants would display a reduced cerebral vascular response to elevated pCO2. Therefore, we evaluated the cerebral vascular response during CO2 challenge tests in groups of term and preterm infants with primary apnea. In term infants (39 ± 2 weeks gestation) with acute life-threatening events, elevated pCO2 was accompanied by decreasing pulsatility index and increasing mean anterior cerebral blood flow velocity. However, in preterm infants (29 ± 2 weeks' gestation) with apnea, pulsatility index and anterior cerebral artery flow velocity did not significantly change in response to CO2 supplementation. We conclude that preterm, but not term, infants with apnea exhibit impaired vascular responses to hypercarbia.

KW - Apnea

KW - Carbon dioxide

KW - Cerebral blood flow

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Cerebral vascular responses to changes in carbon dioxide tension in term and preterm infants with apnea

Abstract

ASJC Scopus subject areas

Keywords

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