Challenges and opportunities for SERS in the infrared: materials and methods

Chiara Deriu; Shaila Thakur; Olimpia Tammaro; Laura Fabris

doi:https://doi.org/10.1039/d2na00930g

Challenges and opportunities for SERS in the infrared: materials and methods

Chiara Deriu, Shaila Thakur, Olimpia Tammaro, Laura Fabris

Research output: Contribution to journal › Review article › peer-review

Abstract

In the wake of a global, heightened interest towards biomarker and disease detection prompted by the SARS-CoV-2 pandemic, surface enhanced Raman spectroscopy (SERS) positions itself again at the forefront of biosensing innovation. But is it ready to move from the laboratory to the clinic? This review presents the challenges associated with the application of SERS to the biomedical field, and thus, to the use of excitation sources in the near infrared, where biological windows allow for cell and through-tissue measurements. Two main tackling strategies will be discussed: (1) acting on the design of the enhancing substrate, which includes manipulation of nanoparticle shape, material, and supramolecular architecture, and (2) acting on the spectral collection set-up. A final perspective highlights the upcoming scientific and technological bets that need to be won in order for SERS to stably transition from benchtop to bedside.

Original language	American English
Pages (from-to)	2132-2166
Number of pages	35
Journal	Nanoscale Advances
Volume	5
Issue number	8
DOIs	https://doi.org/10.1039/d2na00930g
State	Published - Mar 22 2023
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Atomic and Molecular Physics, and Optics
Chemistry(all)
Materials Science(all)
Engineering(all)

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title = "Challenges and opportunities for SERS in the infrared: materials and methods",

abstract = "In the wake of a global, heightened interest towards biomarker and disease detection prompted by the SARS-CoV-2 pandemic, surface enhanced Raman spectroscopy (SERS) positions itself again at the forefront of biosensing innovation. But is it ready to move from the laboratory to the clinic? This review presents the challenges associated with the application of SERS to the biomedical field, and thus, to the use of excitation sources in the near infrared, where biological windows allow for cell and through-tissue measurements. Two main tackling strategies will be discussed: (1) acting on the design of the enhancing substrate, which includes manipulation of nanoparticle shape, material, and supramolecular architecture, and (2) acting on the spectral collection set-up. A final perspective highlights the upcoming scientific and technological bets that need to be won in order for SERS to stably transition from benchtop to bedside.",

author = "Chiara Deriu and Shaila Thakur and Olimpia Tammaro and Laura Fabris",

note = "Funding Information: This project has received funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme (grant agreement No. 865819). Publisher Copyright: {\textcopyright} 2023 RSC.",

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doi = "https://doi.org/10.1039/d2na00930g",

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T2 - materials and methods

AU - Deriu, Chiara

AU - Thakur, Shaila

AU - Tammaro, Olimpia

AU - Fabris, Laura

N1 - Funding Information: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement No. 865819). Publisher Copyright: © 2023 RSC.

PY - 2023/3/22

Y1 - 2023/3/22

N2 - In the wake of a global, heightened interest towards biomarker and disease detection prompted by the SARS-CoV-2 pandemic, surface enhanced Raman spectroscopy (SERS) positions itself again at the forefront of biosensing innovation. But is it ready to move from the laboratory to the clinic? This review presents the challenges associated with the application of SERS to the biomedical field, and thus, to the use of excitation sources in the near infrared, where biological windows allow for cell and through-tissue measurements. Two main tackling strategies will be discussed: (1) acting on the design of the enhancing substrate, which includes manipulation of nanoparticle shape, material, and supramolecular architecture, and (2) acting on the spectral collection set-up. A final perspective highlights the upcoming scientific and technological bets that need to be won in order for SERS to stably transition from benchtop to bedside.

AB - In the wake of a global, heightened interest towards biomarker and disease detection prompted by the SARS-CoV-2 pandemic, surface enhanced Raman spectroscopy (SERS) positions itself again at the forefront of biosensing innovation. But is it ready to move from the laboratory to the clinic? This review presents the challenges associated with the application of SERS to the biomedical field, and thus, to the use of excitation sources in the near infrared, where biological windows allow for cell and through-tissue measurements. Two main tackling strategies will be discussed: (1) acting on the design of the enhancing substrate, which includes manipulation of nanoparticle shape, material, and supramolecular architecture, and (2) acting on the spectral collection set-up. A final perspective highlights the upcoming scientific and technological bets that need to be won in order for SERS to stably transition from benchtop to bedside.

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EP - 2166

JO - Nanoscale Advances

JF - Nanoscale Advances

IS - 8

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Challenges and opportunities for SERS in the infrared: materials and methods

Abstract

ASJC Scopus subject areas

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