@article{563adef2e81f4fadb70bad6f939fc18e,
title = "Chapter 1 A remarkable architectural self-construction process is discovered in a synthesis of FR182877",
author = "Vanderwal, \{Christopher D.\} and Sorensen, \{Erik J.\}",
note = "Funding Information: This chapter describes in detail much of our work on the FR182877 synthetic project; this project was initialized by the authors, David A. Vosburg and Sven Weiler. David was an equal contributor to all of the synthetic work that led up to the synthesis of (+)-FR182877, and Sven contributed greatly to our early efforts. The success of this project is a reflection of their efforts. We gratefully acknowledge the helpful discussions regarding FR182877 with Dr. Seiji Yoshimura, Fujisawa Pharmaceutical Corporation and Professor Albert Eschenmoser. The intellectual contributions from many members of the Sorensen group are greatly appreciated. We thank Drs. D.-H. Huang and L. Pasternack for NMR assistance, Dr. G. Siuzdak for mass spectrometric assistance, and Dr. Raj Chadha for X-ray crystallographic analysis. This work was supported by The Skaggs Institute for Chemical Biology at TSRI, NIH/NCI grant CA85526, a Beckman Young Investigator Award (E.J.S.), a Camille Dreyfus Teacher-Scholar Award (E.J.S.), an Astra-Zeneca Award for Excellence in Organic Chemistry (E.J.S.), an Eli Lilly Grantee Award (E.J.S.), a Pfizer Award for Creativity in Organic Chemistry (E.J.S.) and a research grant from Merck Research Laboratories. Predoctoral fellowships from the National Science and Engineering Research Council of Canada (C.D.V.), the National Science Foundation (D.A.V.), and the ACS Division of Organic Chemistry/AstraZeneca Pharmaceuticals (D.A.V.) are gratefully acknowledged. We also thank Hoffmann-La Roche for a Roche Award for Excellence in Organic Chemistry (C.D.V.) and Bristol-Myers-Squibb for a Bristol-Myers-Squibb Graduate Fellowship (C.D.V.).",
year = "2004",
doi = "10.1016/S1874-6004(04)80024-8",
language = "English (US)",
volume = "5",
pages = "1--50",
journal = "Strategies and Tactics in Organic Synthesis",
issn = "1874-6004",
publisher = "Academic Press Inc.",
number = "C",
}