Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain

Mariagemiliana Dessi; Swetha Kodamasimham; Caroline Wood; Jay C. Sy

Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain

Mariagemiliana Dessi, Swetha Kodamasimham, Caroline Wood, Jay C. Sy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Introduction: Convection-enhanced delivery (CED) provides a flexible platform for local delivery of drugs to brain tissue using a minimally invasive approach. Using a pressure-mediated flow, CED devices can bypass the blood–brain barrier in a targeted and safe manner that can achieve therapeutic drug concentrations and increase drug penetration and efficacy compared to systemic delivery. CED is primarily utilized in neuro-oncology applications, but may have broader applicability for treating other neural disorders, but questions of long-term biocompatibility must be addressed.

Original language	American English
Title of host publication	Society for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publication	The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Publisher	Society for Biomaterials
Pages	433
Number of pages	1
ISBN (Electronic)	9781510883901
State	Published - 2019
Event	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: Apr 3 2019 → Apr 6 2019

Publication series

Name	Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume	40

Conference

Conference	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/Territory	United States
City	Seattle
Period	4/3/19 → 4/6/19

ASJC Scopus subject areas

Biochemistry
Biophysics
Biotechnology
Biomaterials
Materials Chemistry

Cite this

Dessi, M., Kodamasimham, S., Wood, C., & Sy, J. C. (2019). Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 433). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Dessi, Mariagemiliana ; Kodamasimham, Swetha ; Wood, Caroline et al. / Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. pp. 433 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

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title = "Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain",

abstract = "Introduction: Convection-enhanced delivery (CED) provides a flexible platform for local delivery of drugs to brain tissue using a minimally invasive approach. Using a pressure-mediated flow, CED devices can bypass the blood–brain barrier in a targeted and safe manner that can achieve therapeutic drug concentrations and increase drug penetration and efficacy compared to systemic delivery. CED is primarily utilized in neuro-oncology applications, but may have broader applicability for treating other neural disorders, but questions of long-term biocompatibility must be addressed.",

author = "Mariagemiliana Dessi and Swetha Kodamasimham and Caroline Wood and Sy, {Jay C.}",

note = "Publisher Copyright: {\textcopyright} 2019 Omnipress - All rights reserved.; 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence ; Conference date: 03-04-2019 Through 06-04-2019",

year = "2019",

language = "American English",

series = "Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium",

publisher = "Society for Biomaterials",

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Dessi, M, Kodamasimham, S, Wood, C & Sy, JC 2019, Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, pp. 433, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. / Dessi, Mariagemiliana; Kodamasimham, Swetha; Wood, Caroline et al.
Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. p. 433 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Wood, Caroline

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SP - 433

BT - Society for Biomaterials Annual Meeting and Exposition 2019

PB - Society for Biomaterials

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Dessi M, Kodamasimham S, Wood C, Sy JC. Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. p. 433. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain

Abstract

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Conference

ASJC Scopus subject areas

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