Chemical and bioactive constituents from Zanthoxylum simulans

Ih Sheng Chen, Shwu Jen Wu, Ian Lih Tsai, Tian Shung Wu, John M. Pezzuto, Matthias C. Lu, Heebyung Chai, Nanjoo Suh, Che Ming Teng

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine {1} and 6-methylnorchelerythrine {2}, together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline {3} and huajiaosimuline {4}, exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.

Original languageEnglish (US)
Pages (from-to)1206-1211
Number of pages6
JournalJournal of Natural Products
Issue number9
StatePublished - Sep 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


Dive into the research topics of 'Chemical and bioactive constituents from Zanthoxylum simulans'. Together they form a unique fingerprint.

Cite this