Chemical and bioactive constituents from Zanthoxylum simulans

Ih Sheng Chen; Shwu Jen Wu; Ian Lih Tsai; Tian Shung Wu; John M. Pezzuto; Matthias C. Lu; Heebyung Chai; Nanjoo Suh; Che Ming Teng

doi:https://doi.org/10.1021/np50111a003

Chemical and bioactive constituents from Zanthoxylum simulans

Ih Sheng Chen, Shwu Jen Wu, Ian Lih Tsai, Tian Shung Wu, John M. Pezzuto, Matthias C. Lu, Heebyung Chai, Nanjoo Suh, Che Ming Teng

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine {1} and 6-methylnorchelerythrine {2}, together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline {3} and huajiaosimuline {4}, exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.

Original language	English (US)
Pages (from-to)	1206-1211
Number of pages	6
Journal	Journal of Natural Products
Volume	57
Issue number	9
DOIs	https://doi.org/10.1021/np50111a003
State	Published - Sep 1 1994
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

https://doi.org/10.1021/np50111a003

Cite this

@article{65db50d126d44cc287e7022d72d23f53,

title = "Chemical and bioactive constituents from Zanthoxylum simulans",

abstract = "Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine {1} and 6-methylnorchelerythrine {2}, together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline {3} and huajiaosimuline {4}, exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.",

author = "Chen, {Ih Sheng} and Wu, {Shwu Jen} and Tsai, {Ian Lih} and Wu, {Tian Shung} and Pezzuto, {John M.} and Lu, {Matthias C.} and Heebyung Chai and Nanjoo Suh and Teng, {Che Ming}",

year = "1994",

month = sep,

day = "1",

doi = "https://doi.org/10.1021/np50111a003",

language = "English (US)",

volume = "57",

pages = "1206--1211",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Chemical and bioactive constituents from Zanthoxylum simulans

AU - Chen, Ih Sheng

AU - Wu, Shwu Jen

AU - Tsai, Ian Lih

AU - Wu, Tian Shung

AU - Pezzuto, John M.

AU - Lu, Matthias C.

AU - Chai, Heebyung

AU - Suh, Nanjoo

AU - Teng, Che Ming

PY - 1994/9/1

Y1 - 1994/9/1

N2 - Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine {1} and 6-methylnorchelerythrine {2}, together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline {3} and huajiaosimuline {4}, exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.

AB - Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine {1} and 6-methylnorchelerythrine {2}, together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline {3} and huajiaosimuline {4}, exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.

UR - http://www.scopus.com/inward/record.url?scp=0028004138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028004138&partnerID=8YFLogxK

U2 - https://doi.org/10.1021/np50111a003

DO - https://doi.org/10.1021/np50111a003

M3 - Article

C2 - 7798955

VL - 57

SP - 1206

EP - 1211

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 9

ER -

Chemical and bioactive constituents from Zanthoxylum simulans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this