Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases

Arnold B. Barton, Christopher J. Davies, Clyde A. Hutchison, David B. Kaback

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A gene whose product has homology to protein kinases and is closely related to the Aspergillus nidulans nimA cell-cycle gene was identified on chromosome I of the yeast, Saccharomyces cerevisiae. This gene has been temporarily designated FUN52, where FUN is the acronym for 'function unknown now'. In A. nidulans, nimA is required to enter mitosis. In addition, overexpression of nimA causes premature onset of mitosis and cell cycle arrest. In contrast, S. cerevisiae cells that were either deleted for FUN52 or were overexpressing it had no detectable growth phenotypes. FUN52 proved to be the same as the previously identified KIN3 gene [Jones and Rosamond, Gene 90 (1990) 87-92] that was reported to map on chromosome VI.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalGene
Volume117
Issue number1
DOIs
StatePublished - Aug 1 1992

All Science Journal Classification (ASJC) codes

  • Genetics

Keywords

  • DNA sequencing
  • Recombinant DNA
  • nimA cell-cycle gene

Fingerprint

Dive into the research topics of 'Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases'. Together they form a unique fingerprint.

Cite this