Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex

Galina P. Demyanenko, Melitta Camartin, Eva Anton, Ralf Schmid, Guoping Feng, Joshua Sanes, Patricia F. Maness

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

We show that the neural cell recognition molecule Close Homolog of L1 (CHL1) is required for neuronal positioning and dendritic growth of pyramidal neurons in the posterior region of the developing mouse neocortex. CHL1 was expressed in pyramidal neurons in a high-caudal to low-rostral gradient within the developing cortex. Deep layer pyramidal neurons of CHL1-minus mice were shifted to lower laminar positions in the visual and somatosensory cortex and developed misoriented, often inverted apical dendrites. Impaired migration of CHL1-minus cortical neurons was suggested by strikingly slower rates of radial migration in cortical slices, failure to potentiate integrin-dependent haptotactic cell migration in vitro, and accumulation of migratory cells in the intermediate and ventricular/subventricular zones in vivo. The restriction of CHL1 expression and effects of its deletion in posterior neocortical areas suggests that CHL1 may regulate area-specific neuronal connectivity and, by extension, function in the visual and somatosensory cortex.

Original languageEnglish (US)
Pages (from-to)423-437
Number of pages15
JournalNeuron
Volume44
Issue number3
DOIs
StatePublished - Oct 28 2004

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Pyramidal Cells
Dendrites
Cerebral Cortex
Somatosensory Cortex
Visual Cortex
Lateral Ventricles
Neocortex
Integrins
Cell Movement
Neurons
Growth

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Demyanenko, Galina P. ; Camartin, Melitta ; Anton, Eva ; Schmid, Ralf ; Feng, Guoping ; Sanes, Joshua ; Maness, Patricia F. / Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. In: Neuron. 2004 ; Vol. 44, No. 3. pp. 423-437.
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Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. / Demyanenko, Galina P.; Camartin, Melitta; Anton, Eva; Schmid, Ralf; Feng, Guoping; Sanes, Joshua; Maness, Patricia F.

In: Neuron, Vol. 44, No. 3, 28.10.2004, p. 423-437.

Research output: Contribution to journalArticle

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