Coaxial electrospun poly(ε-caprolactone), multiwalled carbon nanotubes, and polyacrylic acid/polyvinyl alcohol scaffold for skeletal muscle tissue engineering

K. D. McKeon-Fischer, D. H. Flagg, J. W. Freeman

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Skeletal muscle repair after injury usually results in scar tissue and decreased functionality. In this study, we coaxially electrospun poly(ε-caprolactone), multiwalled carbon nanotubes, and a hydrogel consisting of polyvinyl alcohol and polyacrylic acid (PCL-MWCNT-H) to create a self-contained nanoactuating scaffold for skeletal muscle tissue replacement. This was then compared to electrospun PCL and PCL-MWCNT scaffolds. All scaffolds displayed some conductivity; however, MWCNT incorporation increased the conductivity. Only the PCL-MWCNT-H actuated when stimulated with 15 and 20 V. The PCL, PCL-MWCNT, and hydrogel only scaffolds demonstrated no reaction when 5, 8, 10, 15, and 20 V were applied. Thus, all components of the PCL-MWCNT-H scaffold are essential for movement. All three PCL-containing scaffolds were biocompatible, but the PCL-MWCNT-H scaffolds displayed more multinucleated cells with actin interaction. After tensile testing, the MWCNT-containing scaffolds had higher strength than the rat and pig skeletal muscle. Although the mechanical properties were higher than muscle, the PCL-MWCNT-H scaffold shows promise as a potential bioartificial nanoactuator for skeletal muscle.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume99 A
Issue number3
DOIs
StatePublished - Dec 1 2011

Fingerprint

carbopol 940
Polyvinyl Alcohol
Multiwalled carbon nanotubes (MWCN)
Polyvinyl alcohols
Scaffolds (biology)
Tissue engineering
Scaffolds
Muscle
Acids
Hydrogels
Tissue
polycaprolactone
Hydrogel
Tensile testing

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Metals and Alloys
  • Biomedical Engineering
  • Biomaterials

Keywords

  • MWCNTs
  • PCL
  • conductive
  • electrospinning
  • hydrogel

Cite this

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abstract = "Skeletal muscle repair after injury usually results in scar tissue and decreased functionality. In this study, we coaxially electrospun poly(ε-caprolactone), multiwalled carbon nanotubes, and a hydrogel consisting of polyvinyl alcohol and polyacrylic acid (PCL-MWCNT-H) to create a self-contained nanoactuating scaffold for skeletal muscle tissue replacement. This was then compared to electrospun PCL and PCL-MWCNT scaffolds. All scaffolds displayed some conductivity; however, MWCNT incorporation increased the conductivity. Only the PCL-MWCNT-H actuated when stimulated with 15 and 20 V. The PCL, PCL-MWCNT, and hydrogel only scaffolds demonstrated no reaction when 5, 8, 10, 15, and 20 V were applied. Thus, all components of the PCL-MWCNT-H scaffold are essential for movement. All three PCL-containing scaffolds were biocompatible, but the PCL-MWCNT-H scaffolds displayed more multinucleated cells with actin interaction. After tensile testing, the MWCNT-containing scaffolds had higher strength than the rat and pig skeletal muscle. Although the mechanical properties were higher than muscle, the PCL-MWCNT-H scaffold shows promise as a potential bioartificial nanoactuator for skeletal muscle.",
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AU - Freeman, J. W.

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