Collagen gene expression in the neomatrix of carcinoma of the breast

Irene L. Wapnir; Harry Southard; Guanghua Chen; Julia Friedman; Charles D. Boyd; Peter S. Amenta

Collagen gene expression in the neomatrix of carcinoma of the breast

Irene L. Wapnir
, Harry Southard
, Guanghua Chen
, Julia Friedman
, Charles D. Boyd
, Peter S. Amenta

Research output: Contribution to journal › Article › peer-review

Abstract

Excessive deposition of extracellular matrix or neomatrix is a characteristic of desmoplastic invasive breast carcinomas. Type I and III collagens are abundant neomatrix components. Archival breast tissue sections were studied using ³⁵S-labeled cDNA probes for α1(I) and α1(III) procollagen and in situ hybridization. Among the 33 invasive breast cancers, hybridization was seen forming a gradient-like pattern in fibroblasts closest to tumor cells. In the 10 ductal carcinomas in situ studied, a ring-like pattern of hybridization was seen in proximity to the basement membrane zone. Adjacent normal and benign tissues did not demonstrate the patterns of hybridization described in malignant tissues. Gene expression for neomatrix interstitial collagens occurs before there is evidence of invasion in carcinoma of the breast.

Original language	American English
Pages (from-to)	308-316
Number of pages	9
Journal	Invasion and Metastasis
Volume	16
Issue number	6
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Cancer Research

Cite this

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title = "Collagen gene expression in the neomatrix of carcinoma of the breast",

abstract = "Excessive deposition of extracellular matrix or neomatrix is a characteristic of desmoplastic invasive breast carcinomas. Type I and III collagens are abundant neomatrix components. Archival breast tissue sections were studied using 35S-labeled cDNA probes for α1(I) and α1(III) procollagen and in situ hybridization. Among the 33 invasive breast cancers, hybridization was seen forming a gradient-like pattern in fibroblasts closest to tumor cells. In the 10 ductal carcinomas in situ studied, a ring-like pattern of hybridization was seen in proximity to the basement membrane zone. Adjacent normal and benign tissues did not demonstrate the patterns of hybridization described in malignant tissues. Gene expression for neomatrix interstitial collagens occurs before there is evidence of invasion in carcinoma of the breast.",

author = "Wapnir, \{Irene L.\} and Harry Southard and Guanghua Chen and Julia Friedman and Boyd, \{Charles D.\} and Amenta, \{Peter S.\}",

year = "1996",

language = "American English",

volume = "16",

pages = "308--316",

journal = "Invasion and Metastasis",

issn = "0251-1789",

publisher = "S. Karger AG",

number = "6",

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TY - JOUR

T1 - Collagen gene expression in the neomatrix of carcinoma of the breast

AU - Wapnir, Irene L.

AU - Southard, Harry

AU - Chen, Guanghua

AU - Friedman, Julia

AU - Boyd, Charles D.

AU - Amenta, Peter S.

PY - 1996

Y1 - 1996

N2 - Excessive deposition of extracellular matrix or neomatrix is a characteristic of desmoplastic invasive breast carcinomas. Type I and III collagens are abundant neomatrix components. Archival breast tissue sections were studied using 35S-labeled cDNA probes for α1(I) and α1(III) procollagen and in situ hybridization. Among the 33 invasive breast cancers, hybridization was seen forming a gradient-like pattern in fibroblasts closest to tumor cells. In the 10 ductal carcinomas in situ studied, a ring-like pattern of hybridization was seen in proximity to the basement membrane zone. Adjacent normal and benign tissues did not demonstrate the patterns of hybridization described in malignant tissues. Gene expression for neomatrix interstitial collagens occurs before there is evidence of invasion in carcinoma of the breast.

AB - Excessive deposition of extracellular matrix or neomatrix is a characteristic of desmoplastic invasive breast carcinomas. Type I and III collagens are abundant neomatrix components. Archival breast tissue sections were studied using 35S-labeled cDNA probes for α1(I) and α1(III) procollagen and in situ hybridization. Among the 33 invasive breast cancers, hybridization was seen forming a gradient-like pattern in fibroblasts closest to tumor cells. In the 10 ductal carcinomas in situ studied, a ring-like pattern of hybridization was seen in proximity to the basement membrane zone. Adjacent normal and benign tissues did not demonstrate the patterns of hybridization described in malignant tissues. Gene expression for neomatrix interstitial collagens occurs before there is evidence of invasion in carcinoma of the breast.

UR - https://www.scopus.com/pages/publications/0030411239

UR - https://www.scopus.com/pages/publications/0030411239#tab=citedBy

M3 - Article

C2 - 9371230

SN - 0251-1789

VL - 16

SP - 308

EP - 316

JO - Invasion and Metastasis

JF - Invasion and Metastasis

IS - 6

ER -

Collagen gene expression in the neomatrix of carcinoma of the breast

Abstract

ASJC Scopus subject areas

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