Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research

Ritesh Kumar; Jongmyung Kim; Matthew P. Deek; Mariam F. Eskander; Prateek Gulhati; Haejin In; Timothy Kennedy; Mihir M. Shah; Miral S. Grandhi; Lyudmyla Berim; Kristen R. Spencer; Russell C. Langan; Howard S. Hochster; Patrick M. Boland; Salma K. Jabbour

doi:10.3390/curroncol30070473

Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research

Ritesh Kumar, Jongmyung Kim, Matthew P. Deek, Mariam F. Eskander, Prateek Gulhati, Haejin In, Timothy Kennedy, Mihir M. Shah, Miral S. Grandhi, Lyudmyla Berim, Kristen R. Spencer, Russell C. Langan, Howard S. Hochster, Patrick M. Boland, Salma K. Jabbour

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

Abstract

Oncological outcomes are improving in gastrointestinal cancer with advancements in systemic therapies, and there is notable potential in combining immunotherapy and radiation therapy (RT) to allow for further improvements. Various preclinical and early phase II studies have shown promising synergy with immunotherapy and RT in gastrointestinal cancer. A few recent phase III studies have shown improved survival with the addition of immunotherapy to standard treatment for gastrointestinal cancer. The timing, duration, sequencing, and integration with other anti-cancer treatments are still areas of ongoing research. We have reviewed the published and ongoing studies of the combinations of immunotherapy and RT in gastrointestinal cancers.

Original language	American English
Pages (from-to)	6432-6446
Number of pages	15
Journal	Current Oncology
Volume	30
Issue number	7
DOIs	https://doi.org/10.3390/curroncol30070473
State	Published - Jul 2023

ASJC Scopus subject areas

Oncology

Keywords

PD L1
immune checkpoint inhibitors
immunotherapy
radiation

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10.3390/curroncol30070473

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Kumar, R., Kim, J., Deek, M. P., Eskander, M. F., Gulhati, P., In, H., Kennedy, T., Shah, M. M., Grandhi, M. S., Berim, L., Spencer, K. R., Langan, R. C., Hochster, H. S., Boland, P. M., & Jabbour, S. K. (2023). Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research. Current Oncology, 30(7), 6432-6446. https://doi.org/10.3390/curroncol30070473

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title = "Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research",

abstract = "Oncological outcomes are improving in gastrointestinal cancer with advancements in systemic therapies, and there is notable potential in combining immunotherapy and radiation therapy (RT) to allow for further improvements. Various preclinical and early phase II studies have shown promising synergy with immunotherapy and RT in gastrointestinal cancer. A few recent phase III studies have shown improved survival with the addition of immunotherapy to standard treatment for gastrointestinal cancer. The timing, duration, sequencing, and integration with other anti-cancer treatments are still areas of ongoing research. We have reviewed the published and ongoing studies of the combinations of immunotherapy and RT in gastrointestinal cancers.",

keywords = "PD L1, immune checkpoint inhibitors, immunotherapy, radiation",

author = "Ritesh Kumar and Jongmyung Kim and Deek, {Matthew P.} and Eskander, {Mariam F.} and Prateek Gulhati and Haejin In and Timothy Kennedy and Shah, {Mihir M.} and Grandhi, {Miral S.} and Lyudmyla Berim and Spencer, {Kristen R.} and Langan, {Russell C.} and Hochster, {Howard S.} and Boland, {Patrick M.} and Jabbour, {Salma K.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jul,

doi = "10.3390/curroncol30070473",

language = "American English",

volume = "30",

pages = "6432--6446",

journal = "Current Oncology",

issn = "1198-0052",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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Kumar, R, Kim, J, Deek, MP , Eskander, MF , Gulhati, P , In, H , Kennedy, T, Shah, MM, Grandhi, MS, Berim, L, Spencer, KR, Langan, RC, Hochster, HS, Boland, PM & Jabbour, SK 2023, 'Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research', Current Oncology, vol. 30, no. 7, pp. 6432-6446. https://doi.org/10.3390/curroncol30070473

TY - JOUR

T1 - Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers

T2 - An Appraisal of the Current Literature and Ongoing Research

AU - Kumar, Ritesh

AU - Kim, Jongmyung

AU - Deek, Matthew P.

AU - Eskander, Mariam F.

AU - Gulhati, Prateek

AU - In, Haejin

AU - Kennedy, Timothy

AU - Shah, Mihir M.

AU - Grandhi, Miral S.

AU - Berim, Lyudmyla

AU - Spencer, Kristen R.

AU - Langan, Russell C.

AU - Hochster, Howard S.

AU - Boland, Patrick M.

AU - Jabbour, Salma K.

PY - 2023/7

Y1 - 2023/7

N2 - Oncological outcomes are improving in gastrointestinal cancer with advancements in systemic therapies, and there is notable potential in combining immunotherapy and radiation therapy (RT) to allow for further improvements. Various preclinical and early phase II studies have shown promising synergy with immunotherapy and RT in gastrointestinal cancer. A few recent phase III studies have shown improved survival with the addition of immunotherapy to standard treatment for gastrointestinal cancer. The timing, duration, sequencing, and integration with other anti-cancer treatments are still areas of ongoing research. We have reviewed the published and ongoing studies of the combinations of immunotherapy and RT in gastrointestinal cancers.

AB - Oncological outcomes are improving in gastrointestinal cancer with advancements in systemic therapies, and there is notable potential in combining immunotherapy and radiation therapy (RT) to allow for further improvements. Various preclinical and early phase II studies have shown promising synergy with immunotherapy and RT in gastrointestinal cancer. A few recent phase III studies have shown improved survival with the addition of immunotherapy to standard treatment for gastrointestinal cancer. The timing, duration, sequencing, and integration with other anti-cancer treatments are still areas of ongoing research. We have reviewed the published and ongoing studies of the combinations of immunotherapy and RT in gastrointestinal cancers.

KW - PD L1

KW - immune checkpoint inhibitors

KW - immunotherapy

KW - radiation

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U2 - 10.3390/curroncol30070473

DO - 10.3390/curroncol30070473

M3 - Review article

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SN - 1198-0052

VL - 30

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EP - 6446

JO - Current Oncology

JF - Current Oncology

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ER -

Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research

Abstract

ASJC Scopus subject areas

Keywords

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