Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups

Amishav Bresler, Vikas Mehta, Bradley A. Schiff, Richard V. Smith, Samer Khader, Gloria Ramos-Rivera, Juan Lin, Steven Libutti, Amanda M. Laird, Thomas J. Ow

Research output: Contribution to journalArticle

Abstract

Background: The Bethesda System standardized the reporting of thyroid cytopathology and created categories to provide an estimation of a nodule's risk of malignancy. There are limited data describing their utility in different racial-ethnic groups. Methods: A retrospective chart review of thyroid fine-needle aspirations (FNA) was performed within our health-care systems. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPVs) were calculated for the total cohort, and racial-ethnic groups. Results: The sensitivity, specificity, PPV, and NPV of the entire cohort was 93%, 77%, 57%, and 97%. Among patients who underwent surgery, African Americans contained a high number of Bethesda II FNAs (63%) compared to Hispanics (48%) and whites (45%). The sensitivity, specificity, and NPV were comparable among groups, the PPV was lowest for African Americans (43%), followed by Hispanics (60%) and whites (69%). Conclusions: The Bethesda system's predictive value may differ among racial-ethnic groups.

Original languageEnglish (US)
Pages (from-to)2340-2345
Number of pages6
JournalHead and Neck
Volume41
Issue number7
DOIs
StatePublished - Jul 1 2019

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Surgical Pathology
Ethnic Groups
Hispanic Americans
Sensitivity and Specificity
African Americans
Thyroid Gland
Fine Needle Biopsy
Delivery of Health Care
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Keywords

  • Bethesda system
  • fine-needle aspiration biopsy
  • prevalence
  • test characteristics
  • thyroid

Cite this

Bresler, A., Mehta, V., Schiff, B. A., Smith, R. V., Khader, S., Ramos-Rivera, G., ... Ow, T. J. (2019). Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups. Head and Neck, 41(7), 2340-2345. https://doi.org/10.1002/hed.25707
Bresler, Amishav ; Mehta, Vikas ; Schiff, Bradley A. ; Smith, Richard V. ; Khader, Samer ; Ramos-Rivera, Gloria ; Lin, Juan ; Libutti, Steven ; Laird, Amanda M. ; Ow, Thomas J. / Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups. In: Head and Neck. 2019 ; Vol. 41, No. 7. pp. 2340-2345.
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Bresler, A, Mehta, V, Schiff, BA, Smith, RV, Khader, S, Ramos-Rivera, G, Lin, J, Libutti, S, Laird, AM & Ow, TJ 2019, 'Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups', Head and Neck, vol. 41, no. 7, pp. 2340-2345. https://doi.org/10.1002/hed.25707

Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups. / Bresler, Amishav; Mehta, Vikas; Schiff, Bradley A.; Smith, Richard V.; Khader, Samer; Ramos-Rivera, Gloria; Lin, Juan; Libutti, Steven; Laird, Amanda M.; Ow, Thomas J.

In: Head and Neck, Vol. 41, No. 7, 01.07.2019, p. 2340-2345.

Research output: Contribution to journalArticle

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AU - Bresler, Amishav

AU - Mehta, Vikas

AU - Schiff, Bradley A.

AU - Smith, Richard V.

AU - Khader, Samer

AU - Ramos-Rivera, Gloria

AU - Lin, Juan

AU - Libutti, Steven

AU - Laird, Amanda M.

AU - Ow, Thomas J.

PY - 2019/7/1

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N2 - Background: The Bethesda System standardized the reporting of thyroid cytopathology and created categories to provide an estimation of a nodule's risk of malignancy. There are limited data describing their utility in different racial-ethnic groups. Methods: A retrospective chart review of thyroid fine-needle aspirations (FNA) was performed within our health-care systems. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPVs) were calculated for the total cohort, and racial-ethnic groups. Results: The sensitivity, specificity, PPV, and NPV of the entire cohort was 93%, 77%, 57%, and 97%. Among patients who underwent surgery, African Americans contained a high number of Bethesda II FNAs (63%) compared to Hispanics (48%) and whites (45%). The sensitivity, specificity, and NPV were comparable among groups, the PPV was lowest for African Americans (43%), followed by Hispanics (60%) and whites (69%). Conclusions: The Bethesda system's predictive value may differ among racial-ethnic groups.

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Bresler A, Mehta V, Schiff BA, Smith RV, Khader S, Ramos-Rivera G et al. Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups. Head and Neck. 2019 Jul 1;41(7):2340-2345. https://doi.org/10.1002/hed.25707