Abstract
We retrospectively compared the clinical state of 14 patients with Parkinson's disease who took pergolide continuously for 63 ± 17 months (Group I) to that of 12 similar patients who started pergolide and then stopped it after 60 ± 5 days (Group II). Disability measured during the ''on'' state did not worsen during the observations period in Group I patients, whereas disability in Group II showed significant deterioration. There were no significant differences in the progression of motor fluctuations between the two groups. Combination treatment with pergolide and levodopa is effective long-term symptomatic therapy for advanced Parkinson's disease and deserves more rigorous study to determine whether or not it also retards progression of Parkinson's disease.
| Original language | American English |
|---|---|
| Pages (from-to) | 165-169 |
| Number of pages | 5 |
| Journal | Clinical Neuropharmacology |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1991 |
ASJC Scopus subject areas
- Pharmacology
- Clinical Neurology
- Pharmacology (medical)
Keywords
- Parkinson's disease
- Pergolide
- Progression
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