Comparison of tablet dissolution using USP apparatus II and TIM-1 gastrointestinal compartment

Nicole Sermabeikian, Daniel Braido, Alberto Cuitiño

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The absorption and dissolution rate of a tablet is necessary in the pharmaceutical industry for the prediction of drug performance in the body. The TIM, created by TNO, is an in vitro model that produces an environment which closely resembles in vivo performance. Here, the stomach is isolated in the TIM and the dissolution process is compared to that of the USP II. Variability in tablet dissolution rates between the TIM and USPII can result from differences in volume of fluid, flow profile, and sampling methods. A comparison of the TIM and USPII release profiles will be made to determine the importance of each of these differences.

Original languageEnglish (US)
Title of host publication10AIChE - 2010 AIChE Annual Meeting, Conference Proceedings
StatePublished - 2010
Event2010 AIChE Annual Meeting, 10AIChE - Salt Lake City, UT, United States
Duration: Nov 7 2010Nov 12 2010

Publication series

NameAIChE Annual Meeting, Conference Proceedings


Other2010 AIChE Annual Meeting, 10AIChE
Country/TerritoryUnited States
CitySalt Lake City, UT

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Chemistry(all)


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