Complete sequences of mcr-1-harboring plasmids from extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacteriaceae

Aiqing Li; Yong Yang; Minhui Miao; Kalyan D. Chavda; José R. Mediavilla; Xiaofang Xie; Ping Feng; Yi Wei Tang; Barry N. Kreiswirth; Liang Chen; Hong Du

doi:10.1128/AAC.00550-16

Complete sequences of mcr-1-harboring plasmids from extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacteriaceae

Aiqing Li
, Yong Yang
, Minhui Miao
, Kalyan D. Chavda
, José R. Mediavilla
, Xiaofang Xie
, Ping Feng
, Yi Wei Tang
, Barry N. Kreiswirth
, Liang Chen
, Hong Du

Center for Discovery and Innovation

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1-carrying plasmids.

Original language	English
Pages (from-to)	4351-4354
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00550-16
State	Published - Jul 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00550-16

Cite this

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title = "Complete sequences of mcr-1-harboring plasmids from extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacteriaceae",

abstract = "Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1-carrying plasmids.",

author = "Aiqing Li and Yong Yang and Minhui Miao and Chavda, \{Kalyan D.\} and Mediavilla, \{Jos{\'e} R.\} and Xiaofang Xie and Ping Feng and Tang, \{Yi Wei\} and Kreiswirth, \{Barry N.\} and Liang Chen and Hong Du",

year = "2016",

month = jul,

doi = "10.1128/AAC.00550-16",

language = "English",

volume = "60",

pages = "4351--4354",

journal = "Antimicrobial Agents and Chemotherapy",

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T1 - Complete sequences of mcr-1-harboring plasmids from extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacteriaceae

AU - Li, Aiqing

AU - Yang, Yong

AU - Miao, Minhui

AU - Chavda, Kalyan D.

AU - Mediavilla, José R.

AU - Xie, Xiaofang

AU - Feng, Ping

AU - Tang, Yi Wei

AU - Kreiswirth, Barry N.

AU - Chen, Liang

AU - Du, Hong

PY - 2016/7

Y1 - 2016/7

N2 - Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1-carrying plasmids.

AB - Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1-carrying plasmids.

UR - https://www.scopus.com/pages/publications/84977091195

U2 - 10.1128/AAC.00550-16

DO - 10.1128/AAC.00550-16

M3 - Article

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SN - 0066-4804

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EP - 4354

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -

Complete sequences of mcr-1-harboring plasmids from extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacteriaceae

Abstract

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ASJC Scopus subject areas

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