Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy

Keyphrases

• Atomic Level 100%
• Unnatural Amino Acids 100%
• Computational Design 100%
• Metalloproteins 100%
• Amino Acids 66%
• Zn2+ 66%
• Ni2+ 66%
• Co2+ 66%
• Design Methodology 33%
• X-ray Crystal Structure 33%
• Binding Site 33%
• Experimental Characterization 33%
• Novel Functions 33%
• Protein Binding 33%
• Fe2+ 33%
• Metal Ions 33%
• Metal Binding Site 33%
• Functional Site 33%
• Genetically Encoded 33%
• Designed Proteins 33%
• Metal Ligand 33%
• Protein-based 33%
• Computational Design Methods 33%
• Design Model 33%
• Bound Water Molecules 33%
• Optimal Location 33%
• All-atom 33%
• Divalent Cations 33%
• Octahedral Coordination 33%
• Coordination Geometry 33%
• RosettaDesign 33%
• Buried Metal 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 100%
• Metalloprotein 100%
• Alanine 80%
• Binding Site 40%
• Zinc Ion 40%
• Divalent Cation 20%
• Metal Ion 20%

Biochemistry, Genetics and Molecular Biology

• Amino Acids 100%
• Metalloprotein 100%
• Alanine 80%
• Binding Site 40%
• Crystal Structure 20%
• X Ray 20%
• Enzyme 20%
• Metal Binding 20%