Connexins in growth control and cancer

TY - CHAP

T1 - Connexins in growth control and cancer

AU - Naus, Christian C.

AU - Goldberg, Gary S.

AU - Sin, Wun Chey

PY - 2005

Y1 - 2005

N2 - Gap junctions, and their constituent connexin proteins, have long been considered to play a role in the control of cell growth and carcinogenesis. The current review will attempt to summarize the evidence supporting the long-held view that gap-junction channels themselves play a preeminent role in controlling cell proliferation and preventing carcinogenesis through mechanisms of direct intercellular communication. In addition, it is timely to address emerging roles of connexin proteins in their own right, not directly in their channel-forming function, i.e., nonjunctional functions.

AB - Gap junctions, and their constituent connexin proteins, have long been considered to play a role in the control of cell growth and carcinogenesis. The current review will attempt to summarize the evidence supporting the long-held view that gap-junction channels themselves play a preeminent role in controlling cell proliferation and preventing carcinogenesis through mechanisms of direct intercellular communication. In addition, it is timely to address emerging roles of connexin proteins in their own right, not directly in their channel-forming function, i.e., nonjunctional functions.

UR - https://www.scopus.com/pages/publications/35048835117

UR - https://www.scopus.com/pages/publications/35048835117#tab=citedBy

U2 - 10.1007/3-540-28621-7_12

DO - 10.1007/3-540-28621-7_12

M3 - Chapter

SN - 3540261567

SN - 9783540261568

SP - 253

EP - 273

BT - Gap Junctions in Development and Disease

PB - Springer Berlin Heidelberg

ER -