Contentious Issues in Gout Management: The Story so Far

Mohamed Talaat, Kyle Park, Naomi Schlesinger

Research output: Contribution to journalReview articlepeer-review


Gout is the most common inflammatory arthritis worldwide. Although gout has been known for antiquity, many challenges still exist in gout management. It is vital to view gout as a chronic disease and not just treat the acute flare. There is a perception of gout as an acute disease requiring treatment only for acute flares. However, to combat the disease, chronic urate-lowering therapy, reducing the serum urate levels to below the saturation threshold of 6.8 mg/dL, and chronic anti-inflammatory prophylaxis, especially during urate-lowering therapy initiation, are needed. In this manuscript, we discuss some of the contentious issues in gout management. These include the timing of urate-lowering therapy initiation, which urate-lowering therapy to chose, should comorbidities influence our treatment, using genetic determinants, and patient perspectives to drive treatment and differences between gout treatment the American College of Physicians and Rheumatology guidelines for gout management: driving care.

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalOpen Access Rheumatology: Research and Reviews
StatePublished - 2021
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology


  • controversies
  • gout
  • treatment


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