Control of energy homeostasis by the lateral hypothalamic area

Mark A. Rossi

doi:10.1016/j.tins.2023.05.010

Control of energy homeostasis by the lateral hypothalamic area

Mark A. Rossi

Robert Wood Johnson Medical School (RWJMS), Child Health Institute of New Jersey (CHINJ)

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

Abstract

The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over motivated behavior, feeding, and energy balance across species. Recent single-cell sequencing studies have defined at least 30 distinct LHA neuron types. Some of these influence specific aspects of energy homeostasis; however, the functions of many LHA cell types remain unclear. This review addresses the rapidly emerging evidence from cell-type-specific investigations that the LHA leverages distinct neuron populations to regulate energy balance through complex connections with other brain regions. It will highlight recent findings demonstrating that LHA control of energy balance extends beyond mere food intake and propose outstanding questions to be addressed by future research.

Original language	American English
Pages (from-to)	738-749
Number of pages	12
Journal	Trends in Neurosciences
Volume	46
Issue number	9
DOIs	https://doi.org/10.1016/j.tins.2023.05.010
State	Published - Sep 2023

ASJC Scopus subject areas

General Neuroscience

Keywords

appetitive and consummatory behavior
body weight regulation
energy balance
hypothalamus
obesity
overeating

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10.1016/j.tins.2023.05.010

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abstract = "The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over motivated behavior, feeding, and energy balance across species. Recent single-cell sequencing studies have defined at least 30 distinct LHA neuron types. Some of these influence specific aspects of energy homeostasis; however, the functions of many LHA cell types remain unclear. This review addresses the rapidly emerging evidence from cell-type-specific investigations that the LHA leverages distinct neuron populations to regulate energy balance through complex connections with other brain regions. It will highlight recent findings demonstrating that LHA control of energy balance extends beyond mere food intake and propose outstanding questions to be addressed by future research.",

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AB - The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over motivated behavior, feeding, and energy balance across species. Recent single-cell sequencing studies have defined at least 30 distinct LHA neuron types. Some of these influence specific aspects of energy homeostasis; however, the functions of many LHA cell types remain unclear. This review addresses the rapidly emerging evidence from cell-type-specific investigations that the LHA leverages distinct neuron populations to regulate energy balance through complex connections with other brain regions. It will highlight recent findings demonstrating that LHA control of energy balance extends beyond mere food intake and propose outstanding questions to be addressed by future research.

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KW - obesity

KW - overeating

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Control of energy homeostasis by the lateral hypothalamic area

Abstract

ASJC Scopus subject areas

Keywords

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