Abstract
A theory for the growth of the cardiac sarcomere and heart size is proposed. The stress-strain environment and O2 consumption are computed for the myocardium using a mechanical model of the left ventricle. Cardiac afterload and preload are maintained constant while the dimensions of the ventricle are altered. It is observed that the computed ventricular dimensions result in normal heart function, based on examination of stroke volume, heart rate, and ventricular pressure. Global quantities were not necessarily optimal. It is theorized that sarcomerogenesis is stimulated by an increase in the fiber stress along the myofibril.
| Original language | American English |
|---|---|
| Pages | 9-10 |
| Number of pages | 2 |
| State | Published - 1989 |
| Event | Proceedings of the Fifteenth Annual Northeast Bioengineering Conference - Boston, MA, USA Duration: Mar 27 1989 → Mar 28 1989 |
Other
| Other | Proceedings of the Fifteenth Annual Northeast Bioengineering Conference |
|---|---|
| City | Boston, MA, USA |
| Period | 3/27/89 → 3/28/89 |
ASJC Scopus subject areas
- General Chemical Engineering