Convenient synthesis of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (iq), and iq-d3

Joseph Ziv, Spencer Knapp, Joseph D. Rosen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The title compounds (5 and 10) were each prepared in four steps from commercially available 5-amino-6-nitroquinoline (1) in 41% overall yield. The key step was the displacement of the methylsulfonyl group of 4 by sodamide.

Original languageEnglish (US)
Pages (from-to)973-980
Number of pages8
JournalSynthetic Communications
Volume18
Issue number9
DOIs
StatePublished - Jun 1 1988

ASJC Scopus subject areas

  • Organic Chemistry

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