Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

Arnold J. Levine, Zhaohui Feng, Tak W. Mak, Han You, Shengkan Jin

Research output: Contribution to journalReview articlepeer-review

278 Scopus citations

Abstract

Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalGenes and Development
Volume20
Issue number3
DOIs
StatePublished - Feb 1 2006

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Keywords

  • Pathway, interactions
  • p53-AKT
  • p53-TOR

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