Coronary circulation in hearts from hibernating, normothermic, and cold-acclimated hamsters

G. F. Merrill, J. T. White, L. W. Krieger

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4 Scopus citations

Abstract

We have investigated the influence of temperature, acute global ischemia, adenosine administration, and alterations in perfusion pressure on the coronary circulation of isolated, perfused spontaneously beating hearts from hibernating, normothermic, and cold-acclimated (nonhibernating) hamsters. No differences in heart rates were observed among groups at either 9 or 38°C. Hearts from hibernating hamsters showed some differences in autoregulatory capacity at both the low and normal temperatures. All hearts exhibited similar responses to 30 s of global ischemia at both temperatures, with a marked reduction in the response at 9°C. Similarly, the magnitude of the vasculature response to adenosine (250μg) at 38 and 9°C was equal in both normothermic and hibernating hearts perfused at 38°C. Responses were abolished in all groups at 9°C. We conclude that the altered ability of hibernating hearts to autoregulate is possibly due to intrinsic differences initiated by hibernation, while the responses to adenosine, and global ischemia are largely temperature-dependent effects.

Original languageEnglish (US)
Pages (from-to)R50-R54
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume10
Issue number1
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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