Creation of genomic methylation patterns

Timothy H. Bestor; Benjamin Tycko

doi:10.1038/ng0496-363

Creation of genomic methylation patterns

Timothy H. Bestor
, Benjamin Tycko

Center for Discovery and Innovation

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

There are two biological properties of genomic methylation patterns that can be regarded as established. First, methylation of 5′-CpG-3′ dinucleotides within promoters represses transcription, often to undetectable levels. Second, in most cases methylation patterns are subject to clonal inheritance. These properties suit methylation patterns for a number of biological roles, although none of the current hypotheses can be regarded as proved or disproved. One hypothesis suggests that the activity of parasitic sequence elements is repressed by selective methylation. Features of invasive sequences that might allow their identification and inactivation are discussed in terms of the genome defense hypothesis. Identification of the cues that direct de novo methylation may reveal the biological role (or roles) of genomic methylation patterns.

Original language	English
Pages (from-to)	363-367
Number of pages	5
Journal	Nature genetics
Volume	12
Issue number	4
DOIs	https://doi.org/10.1038/ng0496-363
State	Published - Apr 1996

ASJC Scopus subject areas

Genetics

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title = "Creation of genomic methylation patterns",

abstract = "There are two biological properties of genomic methylation patterns that can be regarded as established. First, methylation of 5′-CpG-3′ dinucleotides within promoters represses transcription, often to undetectable levels. Second, in most cases methylation patterns are subject to clonal inheritance. These properties suit methylation patterns for a number of biological roles, although none of the current hypotheses can be regarded as proved or disproved. One hypothesis suggests that the activity of parasitic sequence elements is repressed by selective methylation. Features of invasive sequences that might allow their identification and inactivation are discussed in terms of the genome defense hypothesis. Identification of the cues that direct de novo methylation may reveal the biological role (or roles) of genomic methylation patterns.",

author = "Bestor, \{Timothy H.\} and Benjamin Tycko",

year = "1996",

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AU - Bestor, Timothy H.

AU - Tycko, Benjamin

PY - 1996/4

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N2 - There are two biological properties of genomic methylation patterns that can be regarded as established. First, methylation of 5′-CpG-3′ dinucleotides within promoters represses transcription, often to undetectable levels. Second, in most cases methylation patterns are subject to clonal inheritance. These properties suit methylation patterns for a number of biological roles, although none of the current hypotheses can be regarded as proved or disproved. One hypothesis suggests that the activity of parasitic sequence elements is repressed by selective methylation. Features of invasive sequences that might allow their identification and inactivation are discussed in terms of the genome defense hypothesis. Identification of the cues that direct de novo methylation may reveal the biological role (or roles) of genomic methylation patterns.

AB - There are two biological properties of genomic methylation patterns that can be regarded as established. First, methylation of 5′-CpG-3′ dinucleotides within promoters represses transcription, often to undetectable levels. Second, in most cases methylation patterns are subject to clonal inheritance. These properties suit methylation patterns for a number of biological roles, although none of the current hypotheses can be regarded as proved or disproved. One hypothesis suggests that the activity of parasitic sequence elements is repressed by selective methylation. Features of invasive sequences that might allow their identification and inactivation are discussed in terms of the genome defense hypothesis. Identification of the cues that direct de novo methylation may reveal the biological role (or roles) of genomic methylation patterns.

UR - https://www.scopus.com/pages/publications/0030115772

U2 - 10.1038/ng0496-363

DO - 10.1038/ng0496-363

M3 - Review article

C2 - 8630488

SN - 1061-4036

VL - 12

SP - 363

EP - 367

JO - Nature genetics

JF - Nature genetics

IS - 4

ER -

Creation of genomic methylation patterns

Abstract

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