Crystal Structure of C-T-C-T-C-G-A-G-A-G. Implications for the Structure of the Holliday Junction

David S. Goodsell, Kazimierz Grzeskowiak, Richard E. Dickerson

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The structure of the B-DNA decamer of sequence C-T-C-T-C-G-A-G-A-G shows a crossed arrangement of helices in the C2 crystal lattice. This is the fourth example of a crossed arrangement of B-DNA oligomers in a crystal, and in spite of the fact that each of these four crystallizes in a different lattice, all have nearly identical structures at the crossing contact. This ubiquitous crossing arrangement may be used to generate a structure for the Holliday junction that is fully consistent with the available physical data.

Original languageEnglish (US)
Pages (from-to)1022-1029
Number of pages8
JournalBiochemistry
Volume34
Issue number3
DOIs
StatePublished - Jan 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry

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