Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

Philip J. Pye; Kai Rossen; Steven A. Weissman; Ashok Maliakal; Robert A. Reamer; Richard Ball; Nancy N. Tsou; R. P. Volante; Paul J. Reider

doi:10.1002/1521-3765(20020315)8:6

Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

Philip J. Pye
, Kai Rossen
, Steven A. Weissman
, Ashok Maliakal
, Robert A. Reamer
, Richard Ball
, Nancy N. Tsou
, R. P. Volante
, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

Original language	American English
Pages (from-to)	1372-1376
Number of pages	5
Journal	Chemistry - A European Journal
Volume	8
Issue number	6
DOIs	https://doi.org/10.1002/1521-3765(20020315)8:6
State	Published - Mar 15 2002
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Organic Chemistry

Keywords

Asymmetric synthesis
Crystallization-driven transformation
Dihydroxylation
Mitsunobu reaction
Substance P inhibitors

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10.1002/1521-3765(20020315)8:6

Cite this

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title = "Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors",

abstract = "A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.",

keywords = "Asymmetric synthesis, Crystallization-driven transformation, Dihydroxylation, Mitsunobu reaction, Substance P inhibitors",

author = "Pye, \{Philip J.\} and Kai Rossen and Weissman, \{Steven A.\} and Ashok Maliakal and Reamer, \{Robert A.\} and Richard Ball and Tsou, \{Nancy N.\} and Volante, \{R. P.\} and Reider, \{Paul J.\}",

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doi = "10.1002/1521-3765(20020315)8:6",

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T1 - Crystallization-induced diastereoselection

T2 - Asymmetric synthesis of substance P inhibitors

AU - Pye, Philip J.

AU - Rossen, Kai

AU - Weissman, Steven A.

AU - Maliakal, Ashok

AU - Reamer, Robert A.

AU - Ball, Richard

AU - Tsou, Nancy N.

AU - Volante, R. P.

AU - Reider, Paul J.

PY - 2002/3/15

Y1 - 2002/3/15

N2 - A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

AB - A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

KW - Asymmetric synthesis

KW - Crystallization-driven transformation

KW - Dihydroxylation

KW - Mitsunobu reaction

KW - Substance P inhibitors

UR - https://www.scopus.com/pages/publications/0037087492

UR - https://www.scopus.com/pages/publications/0037087492#tab=citedBy

U2 - 10.1002/1521-3765(20020315)8:6

DO - 10.1002/1521-3765(20020315)8:6

M3 - Article

C2 - 11921220

SN - 0947-6539

VL - 8

SP - 1372

EP - 1376

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 6

ER -

Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

Abstract

ASJC Scopus subject areas

Keywords

Access to Document

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