Crystallization of acetaminophen/poly(ethylene oxide) mixtures

Min Yang, Costas Gogos, Peng Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A model drug acetaminophen was mixed with PEO, and the morphology, nucleation numbers, and crystallization kinetics of PEO were altered accordingly. The spherulitic growth rate and isothermal DSC endotherm were analyzed by Hoffman-Lauritzen theory and Avrami theory, respectively. It was found that the fold surface free energy increased significantly with increasing drug content, indicating the chain folding of PEO became much more difficult in the presence of the small molecule drug.

Original languageEnglish (US)
Title of host publication70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012
Pages2074-2079
Number of pages6
Volume3
StatePublished - Sep 11 2012
Event70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012 - Orlando, FL, United States
Duration: Apr 2 2012Apr 4 2012

Other

Other70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012
CountryUnited States
CityOrlando, FL
Period4/2/124/4/12

Fingerprint

Acetaminophen
Crystallization
Polyethylene oxides
Pharmaceutical Preparations
Crystallization kinetics
Free energy
Nucleation
Molecules

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

Cite this

Yang, M., Gogos, C., & Wang, P. (2012). Crystallization of acetaminophen/poly(ethylene oxide) mixtures. In 70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012 (Vol. 3, pp. 2074-2079)
Yang, Min ; Gogos, Costas ; Wang, Peng. / Crystallization of acetaminophen/poly(ethylene oxide) mixtures. 70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012. Vol. 3 2012. pp. 2074-2079
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Yang, M, Gogos, C & Wang, P 2012, Crystallization of acetaminophen/poly(ethylene oxide) mixtures. in 70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012. vol. 3, pp. 2074-2079, 70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012, Orlando, FL, United States, 4/2/12.

Crystallization of acetaminophen/poly(ethylene oxide) mixtures. / Yang, Min; Gogos, Costas; Wang, Peng.

70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012. Vol. 3 2012. p. 2074-2079.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Yang M, Gogos C, Wang P. Crystallization of acetaminophen/poly(ethylene oxide) mixtures. In 70th Annual Technical Conference of the Society of Plastics Engineers 2012, ANTEC 2012. Vol. 3. 2012. p. 2074-2079