Current therapeutic strategies for inflammation following traumatic spinal cord injury

Priyanka L. Singh; Nitin Agarwal; James C. Barrese; Robert F. Heary

doi:https://doi.org/10.3969/j.issn.1673-5374

Current therapeutic strategies for inflammation following traumatic spinal cord injury

Priyanka L. Singh, Nitin Agarwal, James C. Barrese, Robert F. Heary

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Damage from spinal cord injury occurs in two phases – the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult. Apart from damage sustained as a result of direct trauma to the spinal cord, the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury. Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury, and promote significant functional recovery. This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.

Original language	American English
Pages (from-to)	1812-1821
Number of pages	10
Journal	Neural Regeneration Research
Volume	7
Issue number	23
DOIs	https://doi.org/10.3969/j.issn.1673-5374
State	Published - Aug 15 2012

ASJC Scopus subject areas

Developmental Neuroscience

Keywords

Acute spinal cord injury
Erythropoietin
Estrogen
Etanercept
Hypothermia
Inflammation
Neuroprotective
Rolipram
Secondary injury
Treatment

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abstract = "Damage from spinal cord injury occurs in two phases – the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult. Apart from damage sustained as a result of direct trauma to the spinal cord, the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury. Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury, and promote significant functional recovery. This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.",

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AU - Heary, Robert F.

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AB - Damage from spinal cord injury occurs in two phases – the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult. Apart from damage sustained as a result of direct trauma to the spinal cord, the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury. Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury, and promote significant functional recovery. This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.

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KW - Estrogen

KW - Etanercept

KW - Hypothermia

KW - Inflammation

KW - Neuroprotective

KW - Rolipram

KW - Secondary injury

KW - Treatment

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Current therapeutic strategies for inflammation following traumatic spinal cord injury

Abstract

ASJC Scopus subject areas

Keywords

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