Abstract
Mast cells have been linked to rheumatoid arthritis (RA) and are essential to the pathogenesis of RA-like disease in a mouse model. We describe a 34-year-old woman who developed Sjögren's syndrome concurrently with telangiectasia macularis eruptiva perstans (TMEP), a rare form of cutaneous mastocytosis. The patient had sicca symptoms with an abnormal minor salivary gland biopsy and decreased salivary flow, peripheral neuropathy, an 80 pound weight loss, and a macular erythematous rash that exhibited superficial perivascular mast cell infiltrates on biopsy of lesional skin. This case further underscores the link between mast cells and the development of autoimmunity.
Original language | American English |
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Pages (from-to) | 1697-1700 |
Number of pages | 4 |
Journal | Journal of Rheumatology |
Volume | 33 |
Issue number | 8 |
State | Published - Aug 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology
Keywords
- Autoimmunity
- Cutaneous mastocytosis
- Mast cells
- Sjögren's syndrome